2-[(2-{(2R)-2-[(4-chloro-2-heptylphenoxy)methyl]-5-oxo-1-pyrrolidinyl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid | 883978-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-[(2-{(2R)-2-[(4-chloro-2-heptylphenoxy)methyl]-5-oxo-1-pyrrolidinyl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid
• 英文别名: 2-[2-[(2R)-2-[(4-chloro-2-heptylphenoxy)methyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
• CAS: 883978-35-6
• 化学式: C₂₄H₃₁ClN₂O₄S₂
• 分子量: 511.106
• InChiKey: AHRMZABNCOGVQM-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  133
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Medicinal Composition for Inhalation
  申请人：Yamamoto Shigeki

  公开号：US20080114043A1

  公开（公告）日：2008-05-15

  A medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist topically exhibits a prolonged bronchodilating and antiinflammatory effects. Namely, the medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist is useful as a safe preventive and/or a remedy for respiratory diseases (for example, asthma, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, adult respiratory distress syndrome, cystic fibrosis, pulmonary hypertension or the like) without causing any systemic effect such as lowering blood pressure. Thus, a safe and useful remedy for respiratory diseases is provided.

  一种含有EP2激动剂的持续释放型前药的吸入药物组合物，局部表现出持续的支气管扩张和抗炎作用。换言之，含有EP2激动剂的持续释放型前药的吸入药物组合物可作为安全的预防和/或治疗呼吸系统疾病（例如哮喘、肺损伤、肺纤维化、肺气肿、支气管炎、慢性阻塞性肺病、成人呼吸窘迫综合征、囊性纤维化、肺动脉高压等），而不会引起任何降低血压等全身作用。因此，提供了一种安全有效的呼吸系统疾病治疗药物。
• MEDICINAL COMPOSITION FOR INHALATION
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1806148A1

  公开（公告）日：2007-07-11

  A medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist topically exhibits a prolonged bronchodilating and antiinflammatory effects. Namely, the medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist is useful as a safe preventive and/or a remedy for respiratory diseases (for example, asthma, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, adult respiratory distress syndrome, cystic fibrosis, pulmonary hypertension or the like) without causing any systemic effect such as lowering blood pressure. Thus, a safe and useful remedy for respiratory diseases is provided.

  一种吸入用药物组合物含有一种 EP2 激动剂的持续释放型原药，局部使用后具有延长支气管扩张和抗炎作用。也就是说，含有 EP2 激动剂持续释放型原药的吸入用药物组合物可作为呼吸系统疾病（例如哮喘、肺损伤、肺纤维化、肺气肿、支气管炎、慢性阻塞性肺病、成人呼吸窘迫综合征、囊性纤维化、肺动脉高压或类似疾病）的安全预防和/或治疗药物，而不会引起任何全身效应，例如降低血压。因此，我们提供了一种安全有用的治疗呼吸系统疾病的药物。
• US7858650B2
  申请人：——

  公开号：US7858650B2

  公开（公告）日：2010-12-28