3-甲基-2-环丁烯-1,2-二甲酰氯 | 98274-00-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 3-甲基-2-环丁烯-1,2-二甲酰氯
• 中文别名: 2-环丁烯-1,2-二羰基二氯化,3-甲基-
• 英文名称: 3-methyl-cyclobut-2-ene-1,2-dicarbonyl chloride
• 英文别名: 3-Methyl-cyclobut-2-en-1,2-dicarbonylchlorid；3-Methylcyclobut-2-ene-1,2-dicarbonyl dichloride；3-methylcyclobut-2-ene-1,2-dicarbonyl chloride
• CAS: 98274-00-1
• 化学式: C₇H₆Cl₂O₂
• 分子量: 193.029
• InChiKey: ALXKBWMTMATJTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2917209090

反应信息

• 作为反应物：
  描述：

  3-甲基-2-环丁烯-1,2-二甲酰氯 在 乙醇 、 苯 作用下， 生成 hexa-N-methyl-N,N'-(3-methylene-cyclobutane-1,2-diyldimethyl)-di-ammonium; diiodide
  参考文献：
  名称：

  Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate

  摘要：

  Renal function measurements were obtained in 1,703 African Americans with presumed hypertensive nephrosclerosis who were screened for entry into the African-American Study of Hypertension and Kidney Disease (AASK). We examined the effect of race on relationships involving renal variables by comparing African Americans enrolled into the AASK with non-African Americans enrolled into the Modification of Diet in Renal Disease (MDRD) study. We examined the effect of gender on renal variables by comparing African American men and women. We compared various methods for estimating glomerular filtration rate (GFR) with iodine 125-labeled (I-125)-iothalamate GFR. AASK data were also used to derive a new formula for estimating GFR in African Americans. After adjusting for age, sex, and baseline GFR, African American patients on the AASK study were heavier and had larger body surface areas and body mass indices than either MDRD African Americans or non-African Americans. African Americans had greater serum creatinine levels and urinary creatinine excretions for any given level of GFR. Mean GFR was greater in African American men than African American women (59.7 versus 51.7 mL/min/1.73 m(2)), although serum creatinine levels were also greater in men (1.91 versus 1.73 mg/dL). Seventy-eight percent of women with serum creatinine levels between 1.2 and 1.5 mg/dL had GFRs less than 65 mL/min/1.73 m(2). For African Americans in the AASK, GFR was overestimated by the 24-hour creatinine clearance and underestimated by the Cockcroft-Gault formula. A prediction formula developed in the MDRD study more accurately predicted GFR in AASK patients than these measurements. AASK data were also used to derive a new five-term formula for estimating GFR that was slightly more accurate in the African Americans in the AASK than the MDRD formula (median percentage of error, 12.4% for the MDRD formula versus 12.1% for the AASK formula). Important differences exist in renal variables between African Americans and non-African Americans and between African American men and African American women. Formulas using demographic data and readily measured serum values estimate I-125-iothalamate GFR. (C) 2001 by the National Kidney Foundation, Inc.

  DOI：

  10.1053/ajkd.2001.27691
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 作用下， 生成 3-甲基-2-环丁烯-1,2-二甲酰氯
  参考文献：
  名称：

  Chemistry of Cyclobutanes. II. Cyclobutenes from 3-Methylenecyclobutane-1,2-dicarboxylic Anhydride

  摘要：

  DOI：

  10.1021/ja01527a036

文献信息

• 3-hydrocarbo-2-cyclobutene-1, 2-dicarboxylic acids and their preparation
  申请人：DU PONT

  公开号：US02848478A1

  公开（公告）日：1958-08-19