2-(2-(Benzyloxy)-4-bromo-6-hydroxyphenoxy)acetic acid | 956833-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-(Benzyloxy)-4-bromo-6-hydroxyphenoxy)acetic acid
• 英文别名: 2-(4-bromo-2-hydroxy-6-phenylmethoxyphenoxy)acetic acid
• CAS: 956833-38-8
• 化学式: C₁₅H₁₃BrO₅
• 分子量: 353.169
• InChiKey: QGXDUZLGFCHZQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 溴甲苯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以33%的产率得到2-(2-(Benzyloxy)-4-bromo-6-hydroxyphenoxy)acetic acid
  参考文献：
  名称：

  2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity

  摘要：

  2-O-Carboxymethylpyrogallol derivatives (4-17) were synthesized, with their in vitro inhibitory activities against PTP1B and in vivo antihyperglycemic effects examined. Compound 14, the most potent among the series, showed a K-i value of 1.1 mu M against PTP1B, 7-fold lower than that against TC-PTP. When compound 14 was fed to a high-fat diet-induced diabetic mouse model, significant improvements were observed in both the fasting glucose level and glucose tolerance. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.08.019

文献信息

• 2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity
  作者：Bharat Raj Bhattarai、Suja Shrestha、Seung Wook Ham、Kwang Rok Kim、Hyae Gyeong Cheon、Keun-Hyeung Lee、Hyeongjin Cho

  DOI：10.1016/j.bmcl.2007.08.019

  日期：2007.10

  2-O-Carboxymethylpyrogallol derivatives (4-17) were synthesized, with their in vitro inhibitory activities against PTP1B and in vivo antihyperglycemic effects examined. Compound 14, the most potent among the series, showed a K-i value of 1.1 mu M against PTP1B, 7-fold lower than that against TC-PTP. When compound 14 was fed to a high-fat diet-induced diabetic mouse model, significant improvements were observed in both the fasting glucose level and glucose tolerance. (C) 2007 Elsevier Ltd. All rights reserved.