N-methylalanine t-butylester | 1173397-14-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methylalanine t-butylester
• 英文别名: Tert-butyl 2-(methylamino)propanoate
• CAS: 1173397-14-2
• 化学式: C₈H₁₇NO₂
• mdl: MFCD16828839
• 分子量: 159.228
• InChiKey: XDNKVSNTIKZEMC-UHFFFAOYSA-N

物化性质

• 沸点：
  185.0±23.0 °C(Predicted)
• 密度：
  0.918±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Fmoc-DL-脯氨酸 、 N-methylalanine t-butylester 在 三乙胺 、 bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以4.4%的产率得到L-Alanine, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-N-methyl-,1,1-dimethylethyl ester
  参考文献：
  名称：

  [EN] N-METHYL AMINO ACIDS
  [FR] ACIDES N-METHYL AMINES

  摘要：

  这项发明涉及到式(I)或(II)的化合物，制备它们的方法，包括它们的肽和涉及它们的试剂盒。

  公开号：

  WO2004007427A1

文献信息

• An expedient synthesis of 3-acyltetramic acids of the melophlin family from α-aminoesters and immobilized Ph3PCCO
  作者：Rainer Schobert、Carsten Jagusch

  DOI：10.1016/j.tet.2005.01.036

  日期：2005.2

  The naturally occurring 3-acyltetramic acids (3-acylpyrrolidine-2,4-diones) melophlin A, B, C and G were prepared in few steps from α-aminoesters or their hydrochlorides by cyclization with Ph3PCCO under mild conditions. The employment of immobilized, polystyrene-bound ylide greatly simplifies the removal of by-product Ph3PO and of other impurities. Various 3-acylation methods were assessed.

  通过在温和条件下用Ph 3 PCCO环化，由α-氨基酯或其盐酸盐分几步制备天然存在的3-酰基四甲酸（3-酰基吡咯烷-2,4-二酮）melophlin A，B，C和G。固定化的，聚苯乙烯结合的内酯的使用大大简化了副产物Ph 3 PO和其他杂质的去除。评估了各种3-酰化方法。
• CYCLIC PEPTIDES AND USE AS MEDICINES
  申请人：Fu Jiping

  公开号：US20140134132A1

  公开（公告）日：2014-05-15

  The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

  本发明提供了一种化合物I的公式；或其药学上可接受的盐，其中变量R1、R2、R3、R4、R5和A-B在此处定义，这些化合物是非免疫抑制剂、环肽酶结合剂、mPTP阻滞剂，因此可用于预防或治疗HCV感染、中风、多发性硬化、HBV感染、HPV感染、哮喘、癌症、肌萎缩症、败血症、缺血/再灌注损伤和心力衰竭等疾病或紊乱。
• Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US20040176603A1

  公开（公告）日：2004-09-09

  The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula 1 wherein B, X 1 to X 3 and R 1 to R 5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

  本发明涉及一种新的取代氮杂双环化合物，其一般式为1，其中B、X1至X3和R1至R5如权利要求1所定义，其互变异构体、对映异构体、非对映异构体、混合物及其盐，特别是与无机或有机酸或碱形成的生理上可接受的盐，具有有价值的性质。上述一般式I化合物及其互变异构体、对映异构体、非对映异构体、混合物及其盐，特别是与无机或有机酸或碱形成的生理上可接受的盐及其立体异构体具有有价值的药理学性质，特别是抗血栓活性和Xa因子抑制活性。
• MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA
  申请人：Lee Jinbo

  公开号：US20100152099A1

  公开（公告）日：2010-06-17

  The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

  该发明提供了大环化合物及其合成和使用方法。具体而言，该发明提供了调节肿瘤坏死因子α活性和/或用于治疗医学状况（如类风湿性关节炎、银屑病和哮喘）的大环化合物。
• SUBSTITUTED NITROGEN-CONTAINING HETEROBICYCLES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：Priepke Henning

  公开号：US20090181958A1

  公开（公告）日：2009-07-16

  The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula wherein B, X 1 to X 3 and R 1 to R 5 are defined as in claim 1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

  本发明涉及一种新的取代氮含杂双环化合物，其一般式为B，X1至X3和R1至R5如权利要求1所定义，其互变异构体、对映异构体、非对映异构体、其混合物以及其盐，特别是其与无机或有机酸或碱的生理可接受盐，具有有价值的特性。上述一般式I的化合物以及其互变异构体、对映异构体、非对映异构体、其混合物以及其盐，特别是其与无机或有机酸或碱的生理可接受盐和其立体异构体具有有价值的药理特性，特别是抗血栓活性和Xa因子抑制活性。