1-Amino-3-phosphonocyclopentane-1-carboxylic acid | 103439-18-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Amino-3-phosphonocyclopentane-1-carboxylic acid
• CAS: 103439-18-5
• 化学式: C₆H₁₂NO₅P
• 分子量: 209.14
• InChiKey: HBLKDQXEUJOJPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Novel uses for drugs targeting glutamine synthetase
  申请人：NewThera

  公开号：EP1752143A1

  公开（公告）日：2007-02-14

  The present invention relates to novel therapeutic uses of tianeptine, salts, isomers, prodrugs, metabolites and structural analogs thereof. Furthermore, the present invention relates to the use of tianeptine, salts, isomers, pro-drugs, metabolites and structural analogs thereof, in obtaining methods of screening and of developing drugs. Finally, the present invention relates to the novel therapeutic use of other glutamine synthetase (GS) ligands and to the use of these ligands in obtaining methods for screening and developing drugs.

  本发明涉及噻奈普汀、其盐类、异构体、原药、代谢物和结构类似物的新型治疗用途。此外，本发明还涉及噻奈普汀、其盐类、异构体、原药、代谢物和结构类似物在获得药物筛选和开发方法中的用途。最后，本发明涉及其他谷氨酰胺合成酶（GS）配体的新型治疗用途，以及使用这些配体获得筛选和开发药物的方法。
• NOVEL USES FOR DRUGS TARGETING GLUTAMINE SYNTHETASE
  申请人：Roegel Jean-Christophe

  公开号：US20090209474A1

  公开（公告）日：2009-08-20

  The present invention relates to novel therapeutic uses of tianeptine, salts, isomers, pro-drugs, metabolites and structural analogs thereof. Furthermore, the present invention relates to the use of tianeptine, salts, isomers, pro-drugs, metabolites and structural analogs thereof, in obtaining methods of screening and of developing drugs. Finally, the present invention relates to the novel therapeutic use of other glutamine synthetase (GS) ligands and to the use of these ligands in obtaining methods for screening and developing drugs.