2-(2-azidoacetylthio)acetic acid | 1187844-46-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-azidoacetylthio)acetic acid
• 英文别名: 2-(2-Azidoacetyl)sulfanylacetic acid
• CAS: 1187844-46-7
• 化学式: C₄H₅N₃O₃S
• 分子量: 175.168
• InChiKey: YBMOIVGIQNECDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  94
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  t-butyl 2-(2-azidoacetylthio)acetate 在 三氟乙酸 作用下， 以 水 为溶剂， 反应 0.5h， 生成 2-(2-azidoacetylthio)acetic acid
  参考文献：
  名称：

  Synthesis of N-Terminally Linked Protein Dimers and Trimers by a Combined Native Chemical Ligation-CuAAC Click Chemistry Strategy

  摘要：

  A novel method for the synthesis of N-terminally linked protein multimers is reported. Azide and alkyne thioesters were synthesized for the N-terminal modification of expressed proteins using native chemical ligation (NCL). Proteins modified by these moieties can be joined together to form homodimers and homotrimers via Cu(I)-catalyzed azide-alkyne [3 + 2] cycloaddition (CuAAC) click chemistry. The orthogonal nature of this reaction allows the production of protein heteromultimers, and this is demonstrated by synthesis of a protein heterodimer.

  DOI：

  10.1021/ol9016468

文献信息

• Synthesis of N-Terminally Linked Protein Dimers and Trimers by a Combined Native Chemical Ligation-CuAAC Click Chemistry Strategy
  作者：Junpeng Xiao、Thomas J. Tolbert

  DOI：10.1021/ol9016468

  日期：2009.9.17

  A novel method for the synthesis of N-terminally linked protein multimers is reported. Azide and alkyne thioesters were synthesized for the N-terminal modification of expressed proteins using native chemical ligation (NCL). Proteins modified by these moieties can be joined together to form homodimers and homotrimers via Cu(I)-catalyzed azide-alkyne [3 + 2] cycloaddition (CuAAC) click chemistry. The orthogonal nature of this reaction allows the production of protein heteromultimers, and this is demonstrated by synthesis of a protein heterodimer.