1-methoxy-4-(10-undecenyloxymethy)benzene | 627064-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methoxy-4-(10-undecenyloxymethy)benzene
• 英文别名: 1-(4-methoxybenzyloxy)undec-10-ene；1-methoxy-4-((undec-10-en-1-yloxy)methyl)benzene；1-Methoxy-4-(undec-10-enoxymethyl)benzene
• CAS: 627064-10-2
• 化学式: C₁₉H₃₀O₂
• 分子量: 290.446
• InChiKey: NRHMEYAWSVGLBJ-UHFFFAOYSA-N

物化性质

• 沸点：
  374.2±17.0 °C(Predicted)
• 密度：
  0.928±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methoxy-4-(10-undecenyloxymethy)benzene 在 silver hexafluoroantimonate 、 1,3,5-三甲氧基苯 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以99%的产率得到10-十一烯-1-醇
  参考文献：
  名称：

  Silver(I)-Catalyzed Deprotection of p-Methoxybenzyl Ethers: A Mild and Chemoselective Method

  摘要：

  The p-methoxybenzyl protecting group (PMB) on various alcohols and an acid was efficiently and selectively, cleaved by the action of a catalytic amount of silver(I) hexafluoroantimonate combined with 0.5 equiv of 1,3,5-trimethoxybenzene in dichloromethane at 40 degrees C.

  DOI：

  10.1021/jo301787v
• 作为产物：
  描述：

  10-十一烯-1-醇 、 4-甲氧基苄醇 在 sulfated tungstate 作用下， 反应 2.0h， 以87%的产率得到1-methoxy-4-(10-undecenyloxymethy)benzene
  参考文献：
  名称：

  硫酸化钨酸盐作为羟基活化剂用于制备苄基，包括醇和酚的对甲氧基苄基醚

  摘要：

  摘要 硫酸化钨酸盐被发现是一种有效的多相和可重复使用的催化剂，用于在温和的反应条件下羟基活化介导的苄醚制备，包括各种醇和酚的对甲氧基苄醚。图形概要

  DOI：

  10.1080/00397911.2016.1230218

文献信息

• Cobalt-Catalyzed Hydrofluorination of Unactivated Olefins: A Radical Approach of Fluorine Transfer
  作者：Hiroki Shigehisa、Eriko Nishi、Mayu Fujisawa、Kou Hiroya

  DOI：10.1021/ol402696h

  日期：2013.10.18

  Catalytic hydrofluorination of olefins using a cobalt catalyst was developed. The exclusive Markovnikov selectivity, functional group tolerance, and scalability of this reaction make it an attractive protocol for the hydrofluorination of olefins. A preliminary mechanistic experiment showed the involvement of a radical intermediate.

  开发了使用钴催化剂的烯烃的催化氢氟化。该反应专有的马尔可夫尼科夫选择性，官能团耐受性和可扩展性使其成为烯烃氢氟化的有吸引力的方案。初步的机械实验表明，自由基中间体的参与。
• Hydroalkoxylation of Unactivated Olefins with Carbon Radicals and Carbocation Species as Key Intermediates
  作者：Hiroki Shigehisa、Tatsuya Aoki、Sumiko Yamaguchi、Nao Shimizu、Kou Hiroya

  DOI：10.1021/ja405219f

  日期：2013.7.17

  A unique Markovnikov hydroalkoxylation of unactivated olefins with a cobalt complex, silane, and N-fluoropyridinium salt is reported. Further optimization of reaction conditions yielded high functional group tolerance and versatility of alcoholic solvent employed, including methanol, i-propanol, and t-butanol. Use of trifluorotoluene as a solvent made the use of alcohol in stoichiometric amount possible. Mechanistic insight into this novel catalytic system is also discussed. Experimental results suggest that catalysis involves both carbon radical and carbocation intermediates.
• Conversion of Epoxides to 1,3-Dioxolanes Catalyzed by Tin(II) Chloride
  作者：James R. Vyvyan、Jennifer A. Meyer、Korin D. Meyer

  DOI：10.1021/jo035112y

  日期：2003.11.1

  Anhydrous tin(II) chloride is an efficient catalyst for the reaction of epoxides with acetone to prepare 2,2-dimethyl-1,3-dioxolanes (acetonides) in good to excellent yields. Mono-, di-, and trisubstituted epoxides participate equally well in this diastereospecific reaction. The use of single enantiomer epoxides under the reported conditions results in significant erosion of optical activity.
• Identification of Target Protein for Batzelladines as CD4
  作者：Kazuo Nagasawa、Jun Shimokawa

  DOI：10.3987/com-18-s(f)49

  日期：——