methyl 3-fluoro-2-hydroxy-3-phenylprop-2-enoate | 80540-62-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: methyl 3-fluoro-2-hydroxy-3-phenylprop-2-enoate
• CAS: 80540-62-1
• 化学式: C₁₀H₉FO₃
• 分子量: 196.178
• InChiKey: KXAXWKCEJVBLGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  methyl-2-hydroxy-3-phenylacrylate 在 甲醇 、 fluorine 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 生成 methyl 3-fluoro-2-hydroxy-3-phenylprop-2-enoate
  参考文献：
  名称：

  .alpha.-Fluorination of ketones. 1. Direct fluorination of pyruvic acid derivatives by using molecular fluorine

  摘要：

  DOI：

  10.1021/jo00345a042

文献信息

• SUBSTITUTE PYRROLIDINE DERIVATIVES
  申请人：Or Yat Sun

  公开号：US20090053175A1

  公开（公告）日：2009-02-26

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.