4-phenyl-3-(phenylethynyl)oxazolidin-2-one | 1258064-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-phenyl-3-(phenylethynyl)oxazolidin-2-one
• 英文别名: 4-Phenyl-3-(2-phenylethynyl)-1,3-oxazolidin-2-one
• CAS: 1258064-85-5
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.296
• InChiKey: AXICIYQUTXPTCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-phenyl-3-(phenylethynyl)oxazolidin-2-one 、 乙腈 在 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到
  参考文献：
  名称：

  TfOH介导的[2 + 2 + 2]酰胺与两个离散腈的环加成反应：4-氨基嘧啶衍生物的合成†

  摘要：

  在这项研究中，开发了一种精简且原子经济的TfOH介导的酰胺与两个离散腈的[2 + 2 + 2]环加成反应，以合成多取代的4-氨基嘧啶。可以容忍各种官能团以及空间和电子上多样化的反应伙伴。获得的产物具有良好至优异的产率。

  DOI：

  10.1039/c6ra11408c
• 作为产物：
  描述：

  4-phenyl-2-oxazolidinone 、 2,2-dibromostyrene 在 bis(tetrapropylammonium) tetraiododicuprate(I) 、 N,N'-dimethylethylenediamine bis(methanesulfonic acid) 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以80%的产率得到4-phenyl-3-(phenylethynyl)oxazolidin-2-one
  参考文献：
  名称：

  A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

  摘要：

  A stable adduct of Cul with Bu4NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C-N and C-O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results.

  DOI：

  10.1021/jo300905w

文献信息

• Copper-Free Sonogashira Cross-Coupling of Ynamides: Easy Access to ­Various Substituted Ynamides from Nonsubstituted Ynamides
  作者：Hideaki Wakamatsu、Mitsuhiro Takeshita

  DOI：10.1055/s-0030-1258023

  日期：2010.9

  It is demonstrated herein that palladium-catalyzed Sonogashira cross-coupling of ynamides can be accomplished with moderate to good yields of substituted ynamides in the absence of copper salt, and NaOAc plays an important role in this reaction as an additive.

  本文证明，在没有铜盐的情况下，钯催化的亚酰胺的 Sonogashira 交叉偶联反应可以以中等到良好的产率获得取代的亚酰胺，而 NaOAc 作为添加剂在该反应中发挥了重要作用。
• Synthesis of Ketenaminals via Catalyst-Free Hydroamination of Ynamides and Diphenylsulfonimide
  作者：Jian Cao、Lian Yu、Yuan Deng

  DOI：10.1055/s-0034-1379937

  日期：——
• METHOD FOR THE TREATMENT AND/OR PREVENTION OF DAMAGED KERATIN
  申请人：Sivlér, Petter

  公开号：EP3784208A1

  公开（公告）日：2021-03-03
• Functionalized Cyclic Polymers and Methods of Preparing Same
  申请人：University of Florida Research Foundation, Inc.

  公开号：US20220056167A1

  公开（公告）日：2022-02-24

  The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure.
• [EN] FUNCTIONALIZED CYCLIC POLYMERS AND METHODS OF PREPARING SAME<br/>[FR] POLYMÈRES CYCLIQUES FONCTIONNALISÉS ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：UNIV OF FLORIDA RESEARCHFOUNDATION INC

  公开号：WO2020223672A1

  公开（公告）日：2020-11-05

  The disclosure provides a method of preparing a functionalized cyclic polymer the method including reacting a metal-alkylidyne compound, metallacycloalkylene compound, or metallacyclopentadiene compound with a plurality of alkynes to form the functionalized cyclic polymer, wherein at least one alkyne comprises a functional group capable of further reacting to form a modified polymer. Also provided is a stereoregular functionalized cyclic polymer prepared by the method of the disclosure.