8-benzyl-5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 1186503-16-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 8-benzyl-5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
• 英文别名: 8-Benzyl-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
• CAS: 1186503-16-1
• 化学式: C₂₂H₁₆O₆
• 分子量: 376.365
• InChiKey: VUGWSIUKYXTIER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(benzo[d][1,3]dioxol-5-yl)-8-benzyl-5,7-bis(benzyloxy)-4H-chromen-4-one 在 三溴化硼 、 甲醇 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到8-benzyl-5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
  参考文献：
  名称：

  Synthesis of a Range of Polyhydroxy 8-Aryl Flavones

  摘要：

  The 8-iodo flavones formed by cyclization of benzyl-protected chalcones with iodine in dimethyl sulfoxide have been transformed by a Suzuki coupling reaction into a variety of 8-aryl derivatives. Deprotection with boron tribromide has generated a family of new 8-aryl flavones containing four to eight hydroxyl groups.

  DOI：

  10.1080/00397910802710682

文献信息

• Synthesis of a Range of Polyhydroxy 8-Aryl Flavones
  作者：Lesley Larsen、Dong Hee Yoon、Rex T. Weavers

  DOI：10.1080/00397910802710682

  日期：2009.7.21

  The 8-iodo flavones formed by cyclization of benzyl-protected chalcones with iodine in dimethyl sulfoxide have been transformed by a Suzuki coupling reaction into a variety of 8-aryl derivatives. Deprotection with boron tribromide has generated a family of new 8-aryl flavones containing four to eight hydroxyl groups.