7S,8,17R-triHDHA | 623582-58-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7S,8,17R-triHDHA
• 英文别名: (4Z,7S,9E,11E,13Z,15E,17R,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
• CAS: 623582-58-1
• 化学式: C₂₂H₃₂O₅
• 分子量: 376.493
• InChiKey: OIWTWACQMDFHJG-WEXUSCBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7(S)-epoxy-17R-HDHA 生成 7S,8,17R-triHDHA 、 7S,16,17R-triHDHA
  参考文献：
  名称：

  [EN] USE OF DOCOSATRIENES, RESOLVINS AND THEIR STABLE ANALOGS IN THE TREATMENT OF AIRWAY DISEASES AND ASTHMA
  [FR] UTILISATION DE DOCOSATRIENES, RESOLVINES ET LEURS ANALOGUES STABLES POUR LE TRAITEMENT DE MALADIES DES VOIES RESPIRATOIRES ET DE L'ASTHME

  摘要：

  公开号：

  WO2005089744A3

文献信息

• NOVEL ANTI-INFLAMMATORY METABOLITE DERIVED FROM OMEGA-3-TYPE FATTY ACID
  申请人：The University of Tokyo

  公开号：EP2607358A1

  公开（公告）日：2013-06-26

  The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, d ocosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.

  目的是提供一种能克服传统类固醇药物和非甾体抗炎药缺点的化合物。研究发现，由式[化学式 1]、[化学式 5]等独立表示的二十碳五烯酸、二十二碳六烯酸和二十二碳五烯酸的特定环氧单羟基形式对中性粒细胞具有抑制活性。这种化合物可抑制中性粒细胞侵入组织和中性粒细胞的活化，这在急性炎症中是可以观察到的。
• NOVEL ANTI-INFLAMMATORY COMPOUNDS
  申请人：Arita Makoto

  公开号：US20120059061A1

  公开（公告）日：2012-03-08

  An object of the present invention is to provide a compound having a novel structure for overcoming the defects of conventional steroid agents and NSAIDs. It is found that the particular dihydroxy bodies of eicosapentaenoic acid and docosahexaenoic acid, which have not conventionally been known (11,18-dihydroxy eicosapentaenoic acid (11,18-diHEPE), 17,18-dihydroxy eicosapentaenoic acid (17,18-diHEPE) etc.), have activity of inhibiting neutrophil, thereby solving the object. The present invention unexpectedly remarkably inhibits infiltration into a tissue of, and activation of neutrophil found out at acute inflammation. The compound of the present invention is a compound which has not conventionally been known. Therefore, utility as a new therapeutic is provided.
• US8853437B2
  申请人：——

  公开号：US8853437B2

  公开（公告）日：2014-10-07
• US9238634B2
  申请人：——

  公开号：US9238634B2

  公开（公告）日：2016-01-19