1-(6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-pyridazin-3-yl)-piperidin-4-ol | 1174674-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-pyridazin-3-yl)-piperidin-4-ol
• 英文别名: 1-[6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazin-3-yl]piperidin-4-ol
• CAS: 1174674-65-7
• 化学式: C₂₃H₃₂N₄O₂
• 分子量: 396.533
• InChiKey: IRCSUSACGMABQS-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  61.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED PYRIDAZINE DERIVATIVES WHICH HAVE HISTAMINE H3 ANTAGONIST ACTIVITY<br/>[FR] DÉRIVÉS DE PYRIDAZINE SUBSTITUÉS À ACTIVITÉ ANTAGONISTE DES RÉCEPTEURS H3 DE L'HISTAMINE
  申请人：CEPHALON INC

  公开号：WO2009097306A1

  公开（公告）日：2009-08-06

  The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.

  本发明涉及具有组胺H3拮抗活性的化合物，以及它们的使用和制备方法。
• Substituted Pyridazine Derivatives
  申请人：Hudkins Robert L.

  公开号：US20120004231A1

  公开（公告）日：2012-01-05

  The present invention is directed to compounds having histamine H 3 antagonist activity, as well as methods of their use and preparation.

  本发明涉及具有组胺H3拮抗活性的化合物，以及它们的使用和制备方法。
• Substituted pyridazine derivatives
  申请人：Hudkins Robert L.

  公开号：US20100311752A1

  公开（公告）日：2010-12-09

  The present invention is directed to compounds having histamine H 3 antagonist activity, as well as methods of their use and preparation.

  本发明涉及具有组胺H3受体拮抗活性的化合物，以及它们的使用和制备方法。
• Substituted pyridazine derivatives which have histamine H3 antagonist activity
  申请人：CEPHALON, INC.

  公开号：EP2752406A1

  公开（公告）日：2014-07-09

  The present invention is directed to compounds of formula (I) having histamine H3 antagonist activity, as well as methods of their use and preparation. A compound of Formula I:

  本发明涉及具有组胺 H3 拮抗剂活性的式 (I) 化合物及其使用和制备方法。 式 I 的化合物
• SUBSTITUTED PYRIDAZINE DERIVATIVES WHICH HAVE HISTAMINE H3 ANTAGONIST ACTIVITY
  申请人：Cephalon, Inc.

  公开号：EP2252593A1

  公开（公告）日：2010-11-24