(2S)-2-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid | 104010-34-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid
• CAS: 104010-34-6
• 化学式: C₁₁H₁₉NO₆
• 分子量: 261.27
• InChiKey: KAYBMDDQKDUEKL-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Closure device for sealing percutaneous opening in a vessel
  申请人：Teleflex Innovations S.à.r.l.

  公开号：US10016188B2

  公开（公告）日：2018-07-10

  Closure systems, kits and methods for sealing a percutaneous puncture or other opening in a blood vessel wall, body cavity or biopsy tract are disclosed. A closure system can comprise an implant assembly, a delivery assembly, and an introducer sheath. The closure system can further comprise a valve bypass and a dilator. The implant assembly can include an inner member, a sealing membrane, and an outer member, each of which can be delivered by the delivery assembly. The inner member can be extended through the puncture or opening and positioned adjacent an inner tissue surface. The outer member can be positioned adjacent an outer tissue surface. The sealing membrane can have a distal end attached to the inner member, a proximal end including an opening configured to receive the outer member, and a mid-region therebetween. The outer member, when expanded from a delivery configuration to a sealing configuration, can urge the mid-region of the sealing membrane radially outward such that its outer surface can contact and conform to a perimeter edge of the puncture or opening.

  本文公开了用于封闭经皮穿刺或血管壁、体腔或活检道上其他开口的封闭系统、套件和方法。闭合系统可包括植入组件、输送组件和导引鞘。闭合系统还可包括一个阀门旁路和一个扩张器。植入组件可包括内部构件、密封膜和外部构件，每个构件都可由输送组件输送。内构件可穿过穿刺口或开口，并与内组织表面相邻。外层部件可紧邻外层组织表面。密封膜可以有一个连接到内部构件的远端，一个包括一个开口的近端，该开口被配置为接收外部构件，以及两者之间的中间区域。当外部构件从输送构型扩展到密封构型时，可推动密封膜的中区径向向外扩展，从而使其外表面能够接触并贴合穿刺或开口的周边边缘。
• BIODEGRADABLE STENTS WITH CONTROLLED CHANGE OF PHYSICAL PROPERTIES LEADING TO BIOMECHANICAL COMPATIBILITY
  申请人：Boston Scientific Limited

  公开号：EP1492580B1

  公开（公告）日：2012-06-13
• ANCHORAGE DEVICES COMPRISING AN ACTIVE PHARMACEUTICAL INGREDIENT
  申请人：Tyrx, Inc.

  公开号：EP2637713A1

  公开（公告）日：2013-09-18
• POLYMERIC DRUG DELIVERY SYSTEM FOR TREATING SURGICAL COMPLICATIONS
  申请人：Tyrx, Inc.

  公开号：EP3065703A1

  公开（公告）日：2016-09-14
• CLOSURE DEVICE FOR SEALING PERCUTANEOUS OPENING IN A VESSEL
  申请人：Vascular Solutions, Inc.

  公开号：EP3256051A2

  公开（公告）日：2017-12-20