| 873204-09-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 873204-09-2
• 化学式: C₆₃H₉₄N₁₂O₁₄S₂
• 分子量: 1307.64
• InChiKey: WVVWYZZARHYVPB-GBGBWPTHSA-N

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 N-((S)-1-{(S)-5-Amino-1-[(S)-1-((S)-1-aminooxalyl-4-guanidino-butylcarbamoyl)-4-guanidino-butylcarbamoyl]-pentylcarbamoyl}-pentyl)-benzamide
  参考文献：
  名称：

  Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead

  摘要：

  Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a K-i of 43 nM. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.062
• 作为产物：
  描述：

  在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead

  摘要：

  Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a K-i of 43 nM. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.062