O-dimethoxytrityl-2-dimethyl-3-hydroxypropyl amine | 383413-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: O-dimethoxytrityl-2-dimethyl-3-hydroxypropyl amine
• 英文别名: 3-[bis(4-methoxyphenyl)-phenylmethoxy]-2,2-dimethylpropan-1-amine
• CAS: 383413-13-6
• 化学式: C₂₆H₃₁NO₃
• 分子量: 405.537
• InChiKey: ZWVFHGRGUXTDHW-UHFFFAOYSA-N

物化性质

• 沸点：
  530.4±50.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.0
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  53.71
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1,4,5,8-萘四甲酸酐 、 N,N-二甲基乙二胺 、 O-dimethoxytrityl-2-dimethyl-3-hydroxypropyl amine 以 异丙醇 为溶剂， 以25%的产率得到N-(O-dimethoxytrityl-2-dimethyl-3-hydroxypropyl)-N'-[2-(N,N-dimethylamino)-ethyl]-1,4,5,8-naphtalene tetracarboxylic diimide
  参考文献：
  名称：

  Tethered naphthalene diimide intercalators enhance DNA triplex stability

  摘要：

  Naphthalene diimides function as effective intercalators and when tethered to the 5 ' -terminus of a pyrimidine-rich oligonucleotide can contribute significantly to the overall stabilization of DNA triplexes. This stabilization can be further enhanced by alterations to the linker tethering the DNA sequence and the intercalator. Less flexible linkers, and particularly one with a phenyl ring present, appear to permit the stabilization afforded by the bound intercalator to be transferred more effectively to the three-stranded complex. The conjugate containing the phenyl linker exhibits a TM value that is increased by 28 degreesC relative to the unconjugated triplex. That the linker itself contributes to the observed stabilization is clear since introduction of the phenyl linker increases the observed Tm by 11 degreesC relative to a simple flexible linker. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00135-3
• 作为产物：
  描述：

  4,4'-双甲氧基三苯甲基氯 在 palladium on activated charcoal 吡啶 、 4-二甲氨基吡啶 、 sodium azide 、 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 20.0~90.0 ℃ 、344.74 kPa 条件下， 反应 48.0h， 生成 O-dimethoxytrityl-2-dimethyl-3-hydroxypropyl amine
  参考文献：
  名称：

  Tethered naphthalene diimide intercalators enhance DNA triplex stability

  摘要：

  Naphthalene diimides function as effective intercalators and when tethered to the 5 ' -terminus of a pyrimidine-rich oligonucleotide can contribute significantly to the overall stabilization of DNA triplexes. This stabilization can be further enhanced by alterations to the linker tethering the DNA sequence and the intercalator. Less flexible linkers, and particularly one with a phenyl ring present, appear to permit the stabilization afforded by the bound intercalator to be transferred more effectively to the three-stranded complex. The conjugate containing the phenyl linker exhibits a TM value that is increased by 28 degreesC relative to the unconjugated triplex. That the linker itself contributes to the observed stabilization is clear since introduction of the phenyl linker increases the observed Tm by 11 degreesC relative to a simple flexible linker. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00135-3