Tyrosine--hydrogen iodide (1/1) | 29592-76-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tyrosine--hydrogen iodide (1/1)
• 英文别名: (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;hydroiodide
• CAS: 29592-76-5
• 化学式: C9H12INO3
• 分子量: 309.1
• InChiKey: FLEQANSZVWQQRM-QRPNPIFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.96
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  83.6
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• ANTIBACTERIAL AGENT FOR TREATING INFECTIOUS DISEASES OF BACTERIAL ORIGIN
  申请人：Respublikanskoe Gosudarstvennoe Predpriyatie "Nauchnyj Centr Protivoinfekcionnyh Preparatov" Komiteta Promyshlennosti Ministerstva Industrii

  公开号：EP2722053A1

  公开（公告）日：2014-04-23

  The invention relates to medicine, namely to the antimicrobial agent for the treatment of infectious bacterial diseases including hospital infections and drug-resistant TB which represents the ion nanostructured complex (INSC) synthesized from carbohydrates proteins and/or polypeptides (albumins, interleukins, interferons, signaling proteins, etc), which are to enhance the antimicrobial activity in vivo, by activating immune cells that contain at least one terminal amino acid such as Phe, Ala, Val, Ala, Leu, Ile, and others with electron-donor functional groups, iodine and halides of the alkali and alkaline earth elements in the fourth stage at a certain ionic strength; an antibacterial agent increases: the susceptibility of bacteria, including antibiotic-resistant, to antibiotics; activity of monocytes and macrophages; efficiency of antibiotic treatment of hospital infections and drug-resistant TB; it also has antiviral activity, stimulates hematopoietic function of bone marrow; has an antitumor effect and radioprotective properties; in acceptable concentrations of components can be used as non-pharmaceutical agent (BAFS or parapharmaceutical); is presented in the pharmacological form suitable for parenteral, oral, external, or other application. INSC has the formula [(Ln (MeI3) +) y [Me (Lm) I] + x} (Cl-) y + x + k] with M = 30-300 kDa.

  本发明涉及医学，即用于治疗包括医院感染和耐药结核病在内的传染性细菌疾病的抗菌剂，它是由碳水化合物蛋白质和/或多肽（白蛋白、白细胞介素、干扰素、信号蛋白等）合成的离子纳米结构复合物（INSC），通过激活至少含有一个末端氨基酸（如Phe、Ala、Val、Ala、Leu、Iu）的免疫细胞，增强体内的抗菌活性、等）合成的纳米结构复合物（INSC），通过激活至少含有一个末端氨基酸（如 Phe、Ala、Val、Ala、Leu、Ile 等）的免疫细胞，使其在一定的离子强度下，在第四阶段具有电子供体官能团、碘和碱及碱土元素的卤化物，从而增强体内的抗菌活性；增加抗菌剂：它还具有抗病毒活性，刺激骨髓造血功能；具有抗肿瘤作用和放射保护特性；在可接受的成分浓度下，可用作非药物制剂（BAFS 或准药物）；以药理学形式呈现，适合肠外、口服、外用或其他应用。INSC 的分子式为[(Ln (MeI3) +) y [Me (Lm) I] + x} (Cl-) y + x + k]，M = 30-300 kDa。
• Antibacterial agent for treating infectious diseases of bacterial origin
  申请人：Ilin Alexandr Ivanovich

  公开号：US10149890B2

  公开（公告）日：2018-12-11

  The invention relates to medicine, namely to the antimicrobial agent for the treatment of infectious bacterial diseases including hospital infections and drug-resistant TB which represents the ion nanostructured complex (INSC) synthesized from carbohydrates proteins and/or polypeptides (albumins, interleukins, interferons, signaling proteins, etc), which are to enhance the antimicrobial activity in vivo, by activating immune cells that contain at least one terminal amino acid such as Phe, Ala, Val, Ala, Leu, Ile, and others with electron-donor functional groups, iodine and halides of the alkali and alkaline earth elements in the fourth stage at a certain ionic strength; an antibacterial agent increases: the susceptibility of bacteria, including antibiotic-resistant, to antibiotics; activity of monocytes and macrophages; efficiency of antibiotic treatment of hospital infections and drug-resistant TB; it also has antiviral activity, stimulates hematopoietic function of bone marrow; has an antitumor effect and radioprotective properties; in acceptable concentrations of components can be used as non-pharmaceutical agent (BAFS or parapharmaceutical); is presented in the pharmacological form suitable for parenteral, oral, external, or other application. INSC has the formula [(Ln(MeI3)+)y[Me(Lm)I]+x}(Cl−)y+x+k] with M=30-300 kDa.

  本发明涉及医学，即用于治疗包括医院感染和耐药结核病在内的传染性细菌疾病的抗菌剂，它是由碳水化合物蛋白质和/或多肽（白蛋白、白细胞介素、干扰素、信号蛋白等）合成的离子纳米结构复合物（INSC），通过激活至少含有一个末端氨基酸（如Phe、Ala、Val、Ala、Leu、Iu）的免疫细胞，增强体内的抗菌活性、等）合成的纳米结构复合物（INSC），通过激活至少含有一个末端氨基酸（如 Phe、Ala、Val、Ala、Leu、Ile 等）的免疫细胞，使其在一定的离子强度下，在第四阶段具有电子供体功能基团、碘和碱及碱土元素的卤化物，从而增强体内的抗菌活性；增加抗菌剂：它还具有抗病毒活性，刺激骨髓造血功能；具有抗肿瘤作用和放射保护特性；在可接受的成分浓度下，可用作非药物制剂（BAFS 或准药物）；以药理学形式呈现，适合肠外、口服、外用或其他应用。INSC 的分子式为[(Ln(MeI3)+)y[Me(Lm)I]+x}(Cl-)y+x+k]，M=30-300 kDa。