Dodecyl-dimethyl-(11-prop-2-enoyloxyundecyl)azanium;bromide | 412272-31-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dodecyl-dimethyl-(11-prop-2-enoyloxyundecyl)azanium;bromide
• CAS: 412272-31-2
• 化学式: Br*C₂₈H₅₆NO₂
• 分子量: 518.662
• InChiKey: SAKXRFAKYDJRSW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.23
• 重原子数：
  32
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  11-(dimethylamino)undecyl acrylate 、 溴代十二烷 在 对苯二酚 作用下， 反应 12.0h， 生成 Dodecyl-dimethyl-(11-prop-2-enoyloxyundecyl)azanium;bromide
  参考文献：
  名称：

  Synthesis and antimicrobial properties of polymerizable quaternary ammoniums

  摘要：

  Introduction of biocide monomers during the process of polymerization is a promising approach in the development of new permanent non leaching biocide materials. Two series of surfactants monomers, with a quaternary ammonium group as polar head and an acrylic function as the polymerizable moiety, were synthesized and tested to evaluate their surface active properties alongside with their antibacterial and antifungal properties. Four microbial strains were used to perform the study: Pseudomonas aeruginosa, Staphylococcus aureus. Candida albicans and Aspergillus niger. The biocidal efficacy measured by bacterial and fungal growth inhibition expressed as MIC (Minimal Inhibitory Concentration) and MLC (Minimal Lethal Concentration) values was discussed as a function of molecular parameters. All the synthesized surfactant monomers presented bactericidal and fungicidal activities. Increasing the spacer between the acrylic part and the ammonium group has a favourable effect on the MIC and MLC results. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.031

文献信息

• Synthesis and antimicrobial properties of polymerizable quaternary ammoniums
  作者：Laurent Caillier、Elisabeth Taffin de Givenchy、Richard Levy、Yves Vandenberghe、Serge Géribaldi、Frédéric Guittard

  DOI：10.1016/j.ejmech.2009.03.031

  日期：2009.8

  Introduction of biocide monomers during the process of polymerization is a promising approach in the development of new permanent non leaching biocide materials. Two series of surfactants monomers, with a quaternary ammonium group as polar head and an acrylic function as the polymerizable moiety, were synthesized and tested to evaluate their surface active properties alongside with their antibacterial and antifungal properties. Four microbial strains were used to perform the study: Pseudomonas aeruginosa, Staphylococcus aureus. Candida albicans and Aspergillus niger. The biocidal efficacy measured by bacterial and fungal growth inhibition expressed as MIC (Minimal Inhibitory Concentration) and MLC (Minimal Lethal Concentration) values was discussed as a function of molecular parameters. All the synthesized surfactant monomers presented bactericidal and fungicidal activities. Increasing the spacer between the acrylic part and the ammonium group has a favourable effect on the MIC and MLC results. (C) 2009 Elsevier Masson SAS. All rights reserved.