2-[2-chloro-4-(4-fluorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol | 1159001-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-chloro-4-(4-fluorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol
• CAS: 1159001-35-0
• 化学式: C₁₇H₁₅ClFN₃O₂
• 分子量: 347.776
• InChiKey: LDELYMNZOSCAIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1H-1,2,4-三唑 、 2-(2-chloro-4-(4-fluorophenoxy)phenyl)-2-methyloxirane 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以85%的产率得到2-[2-chloro-4-(4-fluorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol
  参考文献：
  名称：

  Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives

  摘要：

  A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by H-1 NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 mu g/mL.

  DOI：

  10.1021/jf900222s

文献信息

• [EN] FUNGICIDAL SUBSTITUTED 2-[2-HALOGENALKYL-4-(PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS<br/>[FR] COMPOSÉS FONGICIDES 2-[2-HALOGENALKYL-4-(PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL SUBSTITUÉS
  申请人：BASF SE

  公开号：WO2013007767A1

  公开（公告）日：2013-01-17

  The present invention relates to substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-l-[1,2,4]triazol-1-yl-ethanol compounds of formula (I) as defined in the description, and the N-oxides, and salts thereof, their preparation and intermediates for preparing them. The invention also relates to the use of these compounds for combating harmful fungi and seed coated with at least one such compound and also to compositions comprising at least one such compound. Formula (I) wherein: R is C1-C2-halogenalkyl, the other variables are as defined in the claims.

  本发明涉及如下所述的化合物的化学式(I)：取代的2-[2-卤代烷基-4-(苯氧基)-苯基]-1-[1,2,4]三唑-1-基乙醇化合物，以及其N-氧化物和盐，它们的制备方法和用于制备它们的中间体。该发明还涉及利用这些化合物来对抗有害真菌，以及至少包含一种这样的化合物的种子包衣和包含至少一种这样的化合物的组合物。其中：R为C1-C2卤代烷基，其他变量如权利要求中所定义。
• [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED OXIRANES AND TRIAZOLES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'OXIRANES ET TRIAZOLES SUBSTITUÉS
  申请人：BASF SE

  公开号：WO2014108286A1

  公开（公告）日：2014-07-17

  The present invention relates to a process for the preparation of the compounds (II) from the respective oxo compounds. Furthermore, he invention relates to a process for the preparation of triazole compounds from oxiranes II.

  本发明涉及一种从相应的醛酮化合物制备化合物（II）的方法。此外，该发明涉及一种从环氧烷（II）制备三唑化合物的方法。
• Fungicidal substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds
  申请人：Dietz Jochen

  公开号：US20140155262A1

  公开（公告）日：2014-06-05

  The present invention relates to substituted 2-[2-halogenalkyl-4-(phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof, their preparation and intermediates for preparing them. The invention also relates to the use of these compounds for combating harmful fungi and seed coated with at least one such compound and also to compositions comprising at least one such compound.

  本发明涉及式I中定义的取代的2-[2-卤代烷基-4-(苯氧基)-苯基]-1-[1,2,4]三唑-1-基乙醇化合物及其N-氧化物和盐，它们的制备和制备它们的中间体。本发明还涉及使用这些化合物对抗有害真菌和至少包含一种这样的化合物的种子涂层，以及包含至少一种这样的化合物的组合物。
• PROCESS FOR THE PREPARATION OF SUBSTITUTED OXIRANES AND TRIAZOLES
  申请人：BASF AGRO B.V.

  公开号：US20160002189A1

  公开（公告）日：2016-01-07

  The present invention relates to a process for the preparation of the compounds II from the respective oxo compounds. Furthermore, he invention relates to a process for the preparation of triazole compounds from oxiranes II.

  本发明涉及一种从相应的氧化物化合物制备化合物II的方法。此外，本发明还涉及一种从环氧丙烷II制备三唑化合物的方法。
• Fungicidal mixtures comprising pyrimidine fungicides
  申请人：BASF SE

  公开号：EP2835052A1

  公开（公告）日：2015-02-11

  The present invention relates to fungicidal mixtures, comprising at least one fungicidally active compound I and at least one pesticide II as defined in the description, and to compositions comprising these mixtures. The invention furthermore relates to the use of the inventive mixtures for controlling phytopathogenic fungi and compositions comprising them. The invention furthermore also relates to compositions comprising the inventive mixtures and seed in an amount of from 1 g to 1000 g active components per 100 kg of seed. The invention furthermore also relates to methods for controlling phytopathogenic fungi, wherein the fungi or the materials, plants, the soil or seed to be protected from fungal attack are treated with an effective amount of a mixture according to the invention. The invention furthermore also relates to processes for preparing the compositions comprising the mixtures according to the invention.

  本发明涉及杀真菌混合物，包括至少一种杀真菌活性化合物 I 和至少一种农药 II（如描述中所定义），以及包含这些混合物的组合物。 本发明还涉及本发明混合物在控制植物病原真菌方面的用途以及包含这些混合物的组合物。本发明还涉及由本发明混合物和种子组成的组合物，其用量为每 100 千克种子 1 克至 1000 克活性成分。此外，本发明还涉及控制植物病原真菌的方法，其中真菌或材料、植物、土壤或种子需用有效量的根据本发明的混合物处理，以防止真菌侵袭。此外，本发明还涉及制备包含根据本发明的混合物的组合物的工艺。