Maleinsaeure-methylester-propylester | 209272-11-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Maleinsaeure-methylester-propylester
• 英文别名: 1-O-methyl 4-O-propyl but-2-enedioate
• CAS: 209272-11-7
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: JZVAJEKUWCBLKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHODS OF ADMINISTERING MONOMETHYL FUMARATE AND PRODRUGS THEREOF HAVING REDUCED SIDE EFFECTS
  申请人：XenoPort, Inc.

  公开号：US20150038499A1

  公开（公告）日：2015-02-05

  Methods of improving patient safety and reducing undesirable side effects for patients considering therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed. In particular, a method of treating a disease in a patient in need of such treatment is provided. The method comprises testing the patient for a propensity for a deficiency in tissue glutathione S-transferase theta 1 enzyme (GSTT1) levels. Thereafter, a therapeutically effective amount of a compound selected from monomethyl fumarate (MMF), a prodrug of monomethyl fumarate, and combinations thereof is administered to the patient. During the treatment of the disease, blood lymphocyte concentration is periodically tested in the patient at a predetermined time interval length that is based on the enzyme level propensity testing result.

  本发明涉及改善患者安全和减少治疗使用单甲基富马酸及其前药所产生的不良副作用的方法。具体而言，本发明提供了一种治疗患者疾病的方法。该方法包括对患者进行组织谷胱甘肽S-转移酶θ1酶（GSTT1）水平缺陷的倾向性测试。随后，向患者施用单甲基富马酸（MMF）、单甲基富马酸前药或其组合的治疗有效量。在治疗疾病期间，以基于酶水平倾向性测试结果的预定时间间隔长度定期检测患者的血淋巴细胞浓度。
• Improved polyurea coatings from dimethyl-substituted polyaspartic ester mixtures
  申请人：Bayer Corporation

  公开号：EP1113032A1

  公开（公告）日：2001-07-04

  A method for making a polyurea coating by: (a) coating a substrate with a coating composition containing effective coating-forming amounts of (i) a polyisocyanate component, and (ii) an polyaspartic ester mixture. The invention also relates to the coatings made by the method, the polyaspartic ester mixtures used to make the coatings, and methods to make the mixtures.

  一种制造聚脲涂层的方法，其方法是(a) 用涂料组合物涂覆基材，该涂料组合物含有有效成膜量的(i)聚异氰酸酯组 分和(ii)聚天冬氨酸酯混合物。本发明还涉及用该方法制造的涂层、用于制造涂层的聚天冬氨酸酯混合物以及制造该混合物的方法。
• Process for producing alpha, beta-unsaturated carboxylic acid esters and catalyst for use in such process
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1123915A1

  公开（公告）日：2001-08-16

  Economical and efficient processes for producing an α, β-unsaturated carboxylic acid heterocycle-inserted ester and an α,β-unsaturated carboxylic acid polyheteroalkylene ester as well as a catalyst suited for use in economically and efficiently producing an α,β-unsaturated carboxylic acid ester are provided. The invention provides (1) a process for producing an α,β-unsaturated carboxylic acid ester which comprises reacting an α,β-unsaturated carboxylic acid ester with a heterocyclic compound, (2) a process for producing an α,β-unsaturated carboxylic acid ester which comprises reacting an α,β-unsaturated carboxylic acid with a heterocyclic compound in the presence of a polymerization inhibitor and a metal oxide catalyst, and (3) a catalyst for the production of an α,β-unsaturated carboxylic acid ester    comprising a metal oxide.

  本发明提供了经济、高效地生产α，β-不饱和羧酸杂环插入酯和α，β-不饱和羧酸聚异链烷烃酯的工艺，以及适用于经济、高效地生产α，β-不饱和羧酸酯的催化剂。 本发明提供 (1）一种生产α，β-不饱和羧酸酯的工艺，它包括使α，β-不饱和羧酸酯与杂环化合物反应、 (2) α，β-不饱和羧酸酯的生产工艺 其中包括使 α，β-不饱和羧酸与杂环化合物反应 在聚合抑制剂和金属氧化物催化剂存在下，以及 (3) α,β-不饱和羧酸酯生产催化剂 包括一种金属氧化物。
• Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
  申请人：Arbor Pharmaceuticals, LLC

  公开号：US10945984B2

  公开（公告）日：2021-03-16

  Methods of reducing undesirable side effects during therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed.

  本研究公开了使用富马酸单甲酯和富马酸单甲酯原药在治疗过程中减少不良副作用的方法。
• Process for producing alpha , beta-unsaturated carboxylic acid esters and catalyst for use in such process
  申请人：Nippon Shokubai Company Ltd.

  公开号：US20010034300A1

  公开（公告）日：2001-10-25

  Economical and efficient processes for producing an &agr;, &bgr;-unsaturated carboxylic acid heterocycle-inserted ester and an &agr;,&bgr;-unsaturated carboxylic acid polyheteroalkylene ester as well as a catalyst suited for use in economically and efficiently producing an &agr;,&bgr;-unsaturated carboxylic acid ester are provided. The invention provides (1) a process for producing an &agr;,&bgr;-unsaturated carboxylic acid ester which comprises reacting an &agr;,&bgr;-unsaturated carboxylic acid ester with a heterocyclic compound, (2) a process for producing an &agr;,&bgr;-unsaturated carboxylic acid ester which comprises reacting an &agr;,&bgr;-unsaturated carboxylic acid with a heterocyclic compound in the presence of a polymerization inhibitor and a metal oxide catalyst, and (3) a catalyst for the production of an &agr;,&bgr;-unsaturated carboxylic acid ester comprising a metal oxide.

  本发明提供了经济、高效地生产&agr;,&bgr;-不饱和羧酸杂环插入酯和&agr;,&bgr;-不饱和羧酸聚异烯烃酯的工艺，以及适合用于经济、高效地生产&agr;,&bgr;-不饱和羧酸酯的催化剂。 本发明提供 (1）一种生产&agr;,&bgr;-不饱和羧酸酯的工艺，它包括使&agr;,&bgr;-不饱和羧酸酯与杂环化合物反应、 (2) 一种生产&agr;,&bgr;-不饱和羧酸酯的工艺，其中包括将&agr;,&bgr;-不饱和羧酸酯与杂环化合物反应。 其中包括使不饱和羧酸与杂环化合物反应 在聚合抑制剂和金属氧化物催化剂存在下反应，以及 (3) 用于生产&agr;,&bgr;-不饱和羧酸酯的催化剂 包括一种金属氧化物。