Unii-Q2T6S838TV | 1173174-97-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Unii-Q2T6S838TV
• 英文别名: (6R)-1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoro-6-hydroxypiperidin-2-one
• CAS: 1173174-97-4
• 化学式: C₁₈H₁₉F₈N₅O₃
• 分子量: 505.4
• InChiKey: DMXWXVXGQLCKOY-VXJOIVPMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE AGENT
  申请人：Lee Chang-Seok

  公开号：US20100274013A1

  公开（公告）日：2010-10-28

  Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.

  本文披露了一种新的化合物，其化学式为(1)，在规范中定义，具有出色的对二肽基肽酶-IV（DPP-IV）的抑制活性，制备方法和包含其作为活性成分的制药组合物。
• US8470836B2
  申请人：——

  公开号：US8470836B2

  公开（公告）日：2013-06-25
• [EN] DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE AGENT<br/>[FR] COMPOSÉS INHIBITEURS DE LA DIPEPTIDYL PEPTIDASE-4, LEURS PROCÉDÉS DE PRÉPARATION, ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSÉS COMME AGENT ACTIF
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009082134A2

  公开（公告）日：2009-07-02

  Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.