methyl 7-[(1R,2R,3R,5R)-5-acetyloxy-2-formyl-3-(oxan-2-yloxy)cyclopentyl]heptanoate | 50999-62-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 7-[(1R,2R,3R,5R)-5-acetyloxy-2-formyl-3-(oxan-2-yloxy)cyclopentyl]heptanoate
• CAS: 50999-62-7；61302-48-5；62561-69-7；65635-08-7
• 化学式: C₂₁H₃₄O₇
• 分子量: 398.497
• InChiKey: HMEIVWIWTZUKAC-RBTJGNDVSA-N

物化性质

• 沸点：
  486.8±45.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Method for preparing prostaglandin derivative
  申请人：Hirata Ryu

  公开号：US20070244333A1

  公开（公告）日：2007-10-18

  Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.

  揭示了一种制备公式（A）的前列腺素衍生物的方法： 将由公式（1）表示的醛与2-氧代烷基膦酸酯在反应溶剂中，在碱性氢氧化物的存在下反应。通过在反应系统中仅使用碱性氢氧化物作为碱，可以通过简单的程序和高产率获得所需的前列腺素衍生物。
• METHOD FOR PREPARING A FATTY ACID DERIVATIVE
  申请人：MATSUKAWA Tatsuya

  公开号：US20130005995A1

  公开（公告）日：2013-01-03

  A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z 1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z 2 is the same as Z 1 except for when Z 1 is Z 2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.

  提供一种制造公式(I)所代表的脂肪酸衍生物的方法，其中Z1为 其中R3是羟基的保护基；该方法包括以下步骤：将公式(II)的化合物与共氧化剂在氮杂莠菜烷-N-氧杂衍生物的存在下反应，其中Z2与Z1相同，除非Z1为，Z2为。
• METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE
  申请人：HIRATA Ryu

  公开号：US20100204489A1

  公开（公告）日：2010-08-12

  Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.

  公开了一种制备式(A)前列腺素衍生物的方法，该方法包括在反应溶剂中，在碱性氢氧化物的存在下，将式(1)表示的醛与2-氧代烷基膦酸酯反应。通过在反应体系中使用碱性氢氧化物作为唯一碱基，可以通过简单的程序和高收率获得所需的前列腺素衍生物。
• $g(v)-SUBSTITUTED PHENYL-PROSTAGLANDIN E DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1114816A1

  公开（公告）日：2001-07-11

  An ω-substituted phenyl-prostaglandin derivative of formula (I), a process for the preparation thereof, a medicament comprising it as active ingredient (all symbols have the same meaning as described in the specification). The compounds of the formula (I) bind strongly on PGE2 receptor (especially subtype EP4) and therefore are useful for the prophylaxis and/or treatment of immune diseases (autoimmune diseases (amyotrophic lateral sclerosis (ALS) etc.), post-transplantation graft rejection, etc.), asthma, abnormal bone formation, neurocyte death, pulmopathy, hepatopathy, etc. They are also related to sleeping disorders and platelet coagulations, and therefore they are also applicable to these diseases.

  一种式(I)的ω-取代苯基-前列腺素衍生物，其制备方法，一种以其为活性成分的药物（所有符号的含义与说明书中描述的相同）。 式（I）化合物与 PGE2 受体（尤其是亚型 EP4）结合力强，因此可用于预防和/或治疗免疫性疾病（自身免疫性疾病（肌萎缩性脊髓侧索硬化症（ALS）等）、移植后移植物排斥等）、哮喘、骨形成异常、神经细胞死亡、肺病、肝病等。它们还与睡眠障碍和血小板凝结有关，因此也适用于这些疾病。
• US4064351A
  申请人：——

  公开号：US4064351A

  公开（公告）日：1977-12-20