N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide | 1185329-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide
• 英文别名: N-[1-[2-[methyl-[2-(4-methylphenoxy)ethyl]amino]-2-oxoethyl]pyrazol-4-yl]-3-phenoxypropanamide
• CAS: 1185329-96-7
• 化学式: C₂₄H₂₈N₄O₄
• 分子量: 436.5
• InChiKey: ZVSKMVAWWBSNOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• IRE1 ACTIVATING COMPOUNDS FOR USE IN THERAPY
  申请人：The Scripps Research Institute

  公开号：US20210008064A1

  公开（公告）日：2021-01-14

  Disclosed herein are compounds, their pharmaceutical salts, and pharmaceutical compositions that selectively activate the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1s) signaling pathway of the unfolded protein response (UPR), but that do not target the IRE1 kinase domain. The compounds are useful in treating diseases or conditions characterized by imbalances in proteostasis within the endoplasrnic reticulum (ER) or secretory pathway, including those not associated with ER stress or activation of UPR
• [EN] IRE1 ACTIVATING COMPOUNDS FOR USE IN THERAPY<br/>[FR] COMPOSÉS ACTIVANT IRE1 À UTILISER EN THÉRAPIE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2021007594A1

  公开（公告）日：2021-01-14

  Disclosed herein are compounds, their pharmaceutical salts, and pharmaceutical compositions that selectively activate the inositol-requiring enzyme 1 (IRE1) / X-box binding protein 1 (XBPls) signaling pathway of the unfolded protein response (UPR), but that do not target the IRE1 kinase domain. The compounds are useful in treating diseases or conditions characterized by imbalances in proteostasis within the endoplasmic reticulum (ER) or secretory pathway, including those not associated with ER stress or activation of UPR.