N-{3-[(4,6-diaminopyrimidin-5-yl)ethynyl]phenyl}-N'-(2-morpholin-4-ylphenyl)urea | 857287-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-{3-[(4,6-diaminopyrimidin-5-yl)ethynyl]phenyl}-N'-(2-morpholin-4-ylphenyl)urea
• 英文别名: 1-[3-[2-(4,6-Diaminopyrimidin-5-yl)ethynyl]phenyl]-3-(2-morpholin-4-ylphenyl)urea
• CAS: 857287-26-4
• 化学式: C₂₃H₂₃N₇O₂
• 分子量: 429.481
• InChiKey: CPTWISRJCXYSKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  131
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] PYRIMIDINES WITH TIE2 (TEK) ACTIVITY<br/>[FR] PYRIMIDINES A ACTIVITE TIE2 (TEK)
  申请人：ASTRAZENECA AB

  公开号：WO2005060969A1

  公开（公告）日：2005-07-07

  The invention relates to a compound of the Formula (I); or salt thereof, wherein R1, R2, R3, R4, R5, R6, A, B, L, n and m are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm blooded animal. The invention also relates to processes for the preparation of said compounds.

  该发明涉及公式（I）的化合物；或其盐，其中R1、R2、R3、R4、R5、R6、A、B、L、n和m如描述中所定义。该发明还涉及所述化合物的药物组合物，所述化合物作为药物的使用以及在温血动物中产生抗血管生成效应的生产。该发明还涉及所述化合物的制备方法。
• Pyrimidines With Tie2 (Tek) Activity
  申请人：Jones Clifford David

  公开号：US20080027076A1

  公开（公告）日：2008-01-31

  The invention relates to a compound of the Formula (I); or salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, B, L, n and m are as defined in the description. The invention also relates to pharmaceutical compositions of said compounds, the use of said compounds as medicaments and in the production of an anti-angiogenic effect in a warm blooded animal. The invention also relates to processes for the preparation of said compounds.

  本发明涉及公式（I）的化合物或其盐，其中R1、R2、R3、R4、R5、R6、A、B、L、n和m如描述中所定义。本发明还涉及所述化合物的制药组合物，所述化合物作为药物和用于在温血动物中产生抗血管生成效应的制剂的生产中使用。本发明还涉及制备所述化合物的过程。
• PYRIMIDINES WITH TIE2 (TEK) ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1737462A1

  公开（公告）日：2007-01-03