N-(1-Methyl-4-piperidinyl)-3-piperidinecarboxamide | 1096841-09-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1-Methyl-4-piperidinyl)-3-piperidinecarboxamide
• 英文别名: N-(1-methylpiperidin-4-yl)piperidine-3-carboxamide
• CAS: 1096841-09-6
• 化学式: C₁₂H₂₃N₃O
• 分子量: 225.33
• InChiKey: JYRUSPZIWKGJTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
  申请人：Array BioPharma, Inc.

  公开号：US20170096425A1

  公开（公告）日：2017-04-06

  Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
• SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
  申请人：Array BioPharma Inc.

  公开号：US20220119396A1

  公开（公告）日：2022-04-21

  Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.