(1R,2R)-[2-(2,3-dimethylbenzenesulfonyl)-3-oxocyclo-pentyl]acetonitrile | 923002-05-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1R,2R)-[2-(2,3-dimethylbenzenesulfonyl)-3-oxocyclo-pentyl]acetonitrile
• CAS: 923002-05-5
• 化学式: C₁₅H₁₇NO₃S
• 分子量: 291.371
• InChiKey: RBARVBMVYURDKL-IUODEOHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.34
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  75.0
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (1R,2R)-[2-(2,3-dimethylbenzenesulfonyl)-3-oxocyclo-pentyl]acetonitrile 、 碘甲烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (R)-[2-(2,3-dimethylbenzenesulfonyl)-3-methoxy-2-cyclopentenyl]acetonitrile 、 (1R,2S)-[2-(2,3-dimethylbenzenesulfonyl)-2-methyl-3-oxocyclopentyl]acetonitrile 、 (1R,2R)-[2-(2,3-dimethylbenzenesulfonyl)-2-methyl-3-oxocyclopentyl]acetonitrile
  参考文献：
  名称：

  Studies on the structure–enantioselectivity relationships in the catalytic asymmetric intramolecular cyclopropanation reaction of α-diazo-β-keto sulfones possessing a methyl-substituted phenyl group

  摘要：

  This manuscript describes studies on structure-enantioselectivity relationships in the catalytic asymmetric intramolecular cyclopropanation (IMCP) reaction of alpha-diazo-beta-keto sulfones possessing a methyl-substituted phenyl group. Enantioselectivity of the IMCP reaction of the alpha-diazo-beta-keto sulfones was varied by the position of a methyl group on the pheny] group in the substrate, and the 2,3-dimethylphenyl sulfone 11h provided the product 12h in 95% yield with 93% ee. This yield is superior to that of the substrate with a mesityl sulfone 11b, and the product 12h is useful because alkylation of its cyclopropane-opened P-keto sulfone derivative 15h provides the C-alkylated product as a major product. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.10.046
• 作为产物：
  描述：

  1-diazo-1-(2,3-dimethylphenylsulfonyl)-5-hexen-2-one 在 copper(I) trifluoromethanesulfonate benzene 、 (4S,4′S)-(-)-2,2′-(3-戊烯基)双(4-异丙基噁唑啉) 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 13.0h， 生成 (1R,2R)-[2-(2,3-dimethylbenzenesulfonyl)-3-oxocyclo-pentyl]acetonitrile
  参考文献：
  名称：

  Studies on the structure–enantioselectivity relationships in the catalytic asymmetric intramolecular cyclopropanation reaction of α-diazo-β-keto sulfones possessing a methyl-substituted phenyl group

  摘要：

  This manuscript describes studies on structure-enantioselectivity relationships in the catalytic asymmetric intramolecular cyclopropanation (IMCP) reaction of alpha-diazo-beta-keto sulfones possessing a methyl-substituted phenyl group. Enantioselectivity of the IMCP reaction of the alpha-diazo-beta-keto sulfones was varied by the position of a methyl group on the pheny] group in the substrate, and the 2,3-dimethylphenyl sulfone 11h provided the product 12h in 95% yield with 93% ee. This yield is superior to that of the substrate with a mesityl sulfone 11b, and the product 12h is useful because alkylation of its cyclopropane-opened P-keto sulfone derivative 15h provides the C-alkylated product as a major product. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.10.046