4-(methoxymethyl)benzohydrazide | 1098351-03-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(methoxymethyl)benzohydrazide
• CAS: 1098351-03-1
• 化学式: C₉H₁₂N₂O₂
• mdl: MFCD11643315
• 分子量: 180.206
• InChiKey: RVYHECTXIMZTMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5-二溴水杨醛 、 4-(methoxymethyl)benzohydrazide 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 以85 %的产率得到4-methoxymethyl-N'-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide
  参考文献：
  名称：

  [EN] ANTI-FUNGALS COMPOUNDS TARGETING THE SYNTHESIS OF FUNGAL SPHINGOLIPIDS
  [FR] COMPOSÉS ANTI-FONGIQUES CIBLANT LA SYNTHÈSE DE SPHINGOLIPIDES FONGIQUES

  摘要：

  The present invention provides a compound having the structure: wherein R3, R4, R5, R6, and R7are each independently, H, halogen, CN, -CF3, -OCF3, -NO2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, -OH, -OAc, -OR13, -COR13, -CH2OR13, -SH, -SR13, -SO2R13, -NH2, -NHR13, - NR14R15, -NHCOR12, or -CONR14R15; R9, R10, R11, and R12are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, -OAc, -COR13, -SH, -SR13, -SO2R13, -NH2, -NHR13, -NR14R15, -NHCOR12, or -CONR14R15; wherein each occurrence of R13is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R14is independently -H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R15is independently -H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein when R14is methyl, R15is not methyl; wherein at least one of R9, R10, R11, and R12is not H; wherein at least one of R3, R4, R5, R6, and R7is not H.

  公开号：

  WO2023060161A1
• 作为产物：
  描述：

  甲醇 、 4-溴甲基苯甲酸甲酯 在 硫酸 、 一水合肼 作用下， 以89 %的产率得到4-(methoxymethyl)benzohydrazide
  参考文献：
  名称：

  [EN] ANTI-FUNGALS COMPOUNDS TARGETING THE SYNTHESIS OF FUNGAL SPHINGOLIPIDS
  [FR] COMPOSÉS ANTI-FONGIQUES CIBLANT LA SYNTHÈSE DE SPHINGOLIPIDES FONGIQUES

  摘要：

  The present invention provides a compound having the structure: wherein R3, R4, R5, R6, and R7are each independently, H, halogen, CN, -CF3, -OCF3, -NO2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, -OH, -OAc, -OR13, -COR13, -CH2OR13, -SH, -SR13, -SO2R13, -NH2, -NHR13, - NR14R15, -NHCOR12, or -CONR14R15; R9, R10, R11, and R12are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, -OAc, -COR13, -SH, -SR13, -SO2R13, -NH2, -NHR13, -NR14R15, -NHCOR12, or -CONR14R15; wherein each occurrence of R13is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R14is independently -H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R15is independently -H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein when R14is methyl, R15is not methyl; wherein at least one of R9, R10, R11, and R12is not H; wherein at least one of R3, R4, R5, R6, and R7is not H.

  公开号：

  WO2023060161A1

文献信息

• [EN] ANTI-FUNGALS COMPOUNDS TARGETING THE SYNTHESIS OF FUNGAL SPHINGOLIPIDS<br/>[FR] COMPOSÉS ANTI-FONGIQUES CIBLANT LA SYNTHÈSE DE SPHINGOLIPIDES FONGIQUES
  申请人：[en]THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：WO2023060161A1

  公开（公告）日：2023-04-13

  The present invention provides a compound having the structure: wherein R3, R4, R5, R6, and R7are each independently, H, halogen, CN, -CF3, -OCF3, -NO2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, -OH, -OAc, -OR13, -COR13, -CH2OR13, -SH, -SR13, -SO2R13, -NH2, -NHR13, - NR14R15, -NHCOR12, or -CONR14R15; R9, R10, R11, and R12are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, -OAc, -COR13, -SH, -SR13, -SO2R13, -NH2, -NHR13, -NR14R15, -NHCOR12, or -CONR14R15; wherein each occurrence of R13is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R14is independently -H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R15is independently -H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein when R14is methyl, R15is not methyl; wherein at least one of R9, R10, R11, and R12is not H; wherein at least one of R3, R4, R5, R6, and R7is not H.