| 1085938-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1085938-06-2
• 化学式: C₈₄H₁₃₄N₈O₁₂
• 分子量: 1448.03
• InChiKey: IYWBSAMLBPTLFY-WZYGVDNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.59
• 重原子数：
  104.0
• 可旋转键数：
  68.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  218.9
• 氢给体数：
  2.0
• 氢受体数：
  20.0

反应信息

• 作为产物：
  描述：

  、 2-[2-(2-叠氮基乙氧基)乙氧基]乙醇 在 tetrakis(acetonitrile)copper(I) hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以27.8 mg的产率得到
  参考文献：
  名称：

  Biotin-functional oligo(p-phenylene vinylene)s synthesized using click chemistry

  摘要：

  Using Cu(1)-catalyzed [3+2] Huisgen 'click' cycloaddition, a rigid rod - like oligo(p-phenylene vinylene) (OPV) was functionalized at both ends with biotin ligands, combining the valuable electro-optical properties of conjugated organic molecules with the biological recognition capability of biotin. Biotin can be placed at variable distances from the oligomer via appropriate length of a hydrophilic spacer, which also serves to regulate the binding capabilities of the two terminal biotin units. To demonstrate this binding potential, networks were formed with streptavidin-coated quantum dots. The synthetic conditions are presented, together with representative optimizations of the key reactions. The organic compounds were analyzed by means of ATR/FTIR, H-1 NMR (200 or 600 MHz), C-13 NMR, 2D NMR (HMBC, HMQC experiments), MS (ESI OF MALDI-TOF), and optical spectroscopy. Networks were imaged with TEM. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.08.080