1-(N,N-diethylaminosulfonyl)-7-azido-2-heptanol | 1427217-51-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-(N,N-diethylaminosulfonyl)-7-azido-2-heptanol
• 英文别名: 7-azido-N,N-diethyl-2-hydroxyheptane-1-sulfonamide
• CAS: 1427217-51-3
• 化学式: C₁₁H₂₄N₄O₃S
• 分子量: 292.403
• InChiKey: LVXINEXRGYAOIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] SULFONE LINKERS<br/>[FR] COUPLEURS AU SULFONE
  申请人：PROLYNX LLC

  公开号：WO2013036857A1

  公开（公告）日：2013-03-14

  Sulfone linkers which couple drugs to carriers of various types are described. These linkers permit the release of the drug over time in a controlled manner. The release occurs through beta-elimination, and does not require enzymatic cleavage. Products of the linkers with both drugs and macromolecules and methods of using them are described as well.

  研究描述了将药物与各种载体耦合的砜键连接剂。这些连接剂允许药物以受控方式随时间释放。释放是通过β-消除而发生的，并不需要酶解。还描述了连接剂与药物和大分子的产物以及它们的使用方法。
• SEALANTS HAVING CONTROLLED DEGRATION
  申请人：PROLYNX LLC

  公开号：US20150352246A1

  公开（公告）日：2015-12-10

  The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.

  本发明提供了密封剂，其中提供了不含有蛋白质反应性基团以结合膜或组织的可生物降解水凝胶，该基团可以通过连接剂选择性引入。连接剂可以是可生物降解的，并且可以通过消除反应进行生物降解。本发明还提供了多层凝胶用于药物传递，其中与要传递药物的组织或器官接触的多孔凝胶被微孔层保护免受周围体液的影响。
• SEALANTS HAVING CONTROLLED DEGRADATION
  申请人：Prolynx LLC

  公开号：EP2925256A1

  公开（公告）日：2015-10-07
• [EN] SEALANTS HAVING CONTROLLED DEGRADATION<br/>[FR] PRODUITS D'ÉTANCHÉITÉ AYANT UNE DÉGRADATION CONTRÔLÉE
  申请人：PROLYNX LLC

  公开号：WO2014116717A1

  公开（公告）日：2014-07-31

  The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.