2,3-Dimethoxy-5,6,8,8a,9,10,11,12,12a,12b-decahydro-isoindolo[1,2-a]isoquinoline | 26478-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2,3-Dimethoxy-5,6,8,8a,9,10,11,12,12a,12b-decahydro-isoindolo[1,2-a]isoquinoline
• 英文别名: 2,3-dimethoxy-8ar,12ac,12ξ-5,6,8,8a,9,10,11,12,12a,12b-decahydro-isoindolo[1,2-a]isoquinoline；2,3-Dimethoxy-8ar,12ac,12ξ-5,6,8,8a,9,10,11,12,12a,12b-decahydro-isoindolo[1,2-a]isochinolin
• CAS: 26478-04-6
• 化学式: C₁₈H₂₅NO₂
• 分子量: 287.402
• InChiKey: BNNRDYAMERBLJC-LPOUJYBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  21.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  21.7
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 在 zinc-cadmium-amalgam 、 硫酸 、 水 作用下， 生成 2,3-Dimethoxy-5,6,8,8a,9,10,11,12,12a,12b-decahydro-isoindolo[1,2-a]isoquinoline
  参考文献：
  名称：

  The use of interlocked ‘customised’ blade plates in the treatment of metaphyseal fractures in patients with poor bone stock

  摘要：

  Balanced and stable fixation in metaphyseal fractures and nonunion can be difficult because of osteoporosis, disuse osteopenia, comminution, joint proximity or malignant infiltration. Five patients with nonunion and four with comminuted or pathological acute fractures of metaphyseal areas of the tibia or humerus were treated with a 'customised' interlocked blade plate. The plates are standard AO dynamic compression plates of a suitable length that are bent to an acute angle in an industrial vice and 'interlocked'. The nine patients with a mean age of 62.2 years (range 30-91) were followed up for a mean of 7.2 months.At follow-up all fractures had healed with a single complication of subacromial impingement in a patient with a proximal humeral fracture. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0020-1383(99)00278-8