9-phenethyloxy-nonanoic acid | 1192596-51-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-phenethyloxy-nonanoic acid
• 英文别名: 9-(2-Phenylethoxy)nonanoic acid
• CAS: 1192596-51-2
• 化学式: C₁₇H₂₆O₃
• 分子量: 278.392
• InChiKey: NOQDDKNSFDPUCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES
  申请人：Andjelkovic Mirjana

  公开号：US20090270505A1

  公开（公告）日：2009-10-29

  This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A 1 , A 2 , R 1 , m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.

  这项发明涉及新颖的4-二甲基氨基丁酸衍生物，其化学式如下：其中A1、A2、R1、m和n的定义如描述和索赔中所述，以及其药学上可接受的盐。这些化合物抑制肉碱棕榈酰基转移酶（CPT）活性，特别是CPT2活性，并可用作药物治疗受CPT2抑制剂调节的疾病的方法中的药物。
• US8344027B2
  申请人：——

  公开号：US8344027B2

  公开（公告）日：2013-01-01
• [EN] 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES<br/>[FR] DÉRIVÉS D'ACIDE 4-DIMÉTHYLAMINOBUTYRIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009132978A1

  公开（公告）日：2009-11-05

  This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula (I) wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.