cis-2,3,4,6,7,8-hexahydro-6-hydroxy-7-methyl-5(1H)-quinolinone | 1454286-92-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: cis-2,3,4,6,7,8-hexahydro-6-hydroxy-7-methyl-5(1H)-quinolinone
• 英文别名: (6S,7S)-6-hydroxy-7-methyl-2,3,4,6,7,8-hexahydro-1H-quinolin-5-one
• CAS: 1454286-92-0
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: GNTAZKMFZMVOIV-RCOVLWMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.59
• 重原子数：
  13.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  49.33
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  [(7S)-7-methyl-5-oxo-1-(2,2,2-trifluoroacetyl)-2,3,4,6,7,8-hexahydroquinolin-6-yl] acetate 在 甲醇 、 potassium carbonate 作用下， 反应 6.0h， 以106 mg的产率得到trans-2,3,4,6,7,8-hexahydro-6-hydroxy-7-methyl-5(1H)-quinolinone
  参考文献：
  名称：

  Mn(OAc)3-Based α’-Oxidative Acetoxylation of N-Trifluoroacetyl Vinylogous Amides

  摘要：

  Vinylogous amides 1 and 11 are oxidized by dried Mn(OAc)(3) in benzene at 90 degrees C to pyridines 5 and 12, respectively, whereas the analogous N-trifluoroacetyl vinylogous amides 6 and 13 are oxidized by dried Mn(OAc)(3) in benzene at 120 degrees C to give acetates 7 and 14. The alpha'-oxo radicals that are generated in this oxidation cyclize to proximal double bonds to give tricylic alkenes such as 20.

  DOI：

  10.3987/com-12-s(n)95