[(R)-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-ylcarbamoyl)-phenyl-methyl]-carbamic acid tert-butyl ester | 54493-82-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(R)-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-ylcarbamoyl)-phenyl-methyl]-carbamic acid tert-butyl ester
• 英文别名: 7β-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-cephalosporadesic acid lactone
• CAS: 54493-82-2
• 化学式: C₂₁H₂₃N₃O₆S
• 分子量: 445.496
• InChiKey: JMAROILYRXAKSM-HBUWYVDXSA-N

反应信息

• 作为产物：
  描述：

  (6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-hydroxymethyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 在 吡啶 、 chromium(VI) oxide 作用下， 以 二氯甲烷 为溶剂， 生成 [(R)-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-ylcarbamoyl)-phenyl-methyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Neue ?-Lactam-Antibiotika. �ber die Darstellung und Decarbonylierung von 3-Formylcephem-Verbindungen. Modifikationen von Antibiotica, 12. Mitteilung [1]

  摘要：

  AbstractBenzhydrylic esters of 3‐unsubstituted cephem‐4‐carboxylic acids of types 9 and 10 (Scheme 2) are prepared by decarbonylation of esters of 3‐formylcephem compounds of type 2 with tris‐triphenylphosphine‐rhodium chloride. The preparation of the starting materials 2 and 5, as well as of the nucleus 13 is described.

  DOI：

  10.1002/hlca.19740570715