5,8,11-all-cis-tetradecatrienoic acid | 69861-67-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5,8,11-all-cis-tetradecatrienoic acid
• 英文别名: 5Z,8Z,11Z-tetradecatrienoic acid；(5Z,8Z,11Z)-tetradeca-5,8,11-trienoic acid
• CAS: 69861-67-2
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.327
• InChiKey: OGNXSHDOHVRKCU-PDBXOOCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,8,11-all-cis-tetradecatrienoic acid 在 吡啶 、 lead(IV) acetate 、 copper diacetate 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 1,4,7,10-Tridecatetraen
  参考文献：
  名称：

  Boland, Wilhelm; Jaenicke, Lothar, Liebigs Annalen der Chemie, 1981, # 1, p. 92 - 98

  摘要：

  DOI：

文献信息

• METHODS FOR MODULATING IKS CHANNEL ACTIVITY
  申请人：ELINDER Fredrik

  公开号：US20170216240A1

  公开（公告）日：2017-08-03

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“PUFAs”) to modulate I ks channels to treat conditions associated with a disruption in I ks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pK a values, which can activate (i.e., open) I Ks channels, and positively charged PUFAs that can inhibit (i.e., close) I KS channels.
• US9999626B2
  申请人：——

  公开号：US9999626B2

  公开（公告）日：2018-06-19
• [EN] METHODS FOR MODULATING IKS CHANNEL ACTIVITY<br/>[FR] PROCÉDÉS PERMETTANT DE MODULER L'ACTIVITÉ DES CANAUX IKS
  申请人：UNIV MIAMI

  公开号：WO2016022567A2

  公开（公告）日：2016-02-11

  Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof ("PUFAs") to modulate Iks channels to treat conditions associated with a disruption in Iks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged PUFAs having decreased pKa values, which can activate (i.e., open) IKs channels, and positively charged PUFAs that can inhibit (i.e., close) IKS channels.