ethyl 9-anthryloxyacetate | 479621-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: ethyl 9-anthryloxyacetate
• 英文别名: anthracen-9-yloxy acetic acid ethyl ester；Ethyl 2-anthracen-9-yloxyacetate
• CAS: 479621-18-6
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: SYJJOZHWEMZQLR-UHFFFAOYSA-N

物化性质

• 沸点：
  445.9±18.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 9-anthryloxyacetate 在 乙醇 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 40.25h， 生成 2-(anthracen-9-yloxy)-N-((2S,3S)-1,3-dihydroxybutan-2-yl)acetamide
  参考文献：
  名称：

  Genetic probe for the detection of a single nucleotide polymorphism (SNP) or a single nucleotide modification of a target nucleic acid

  摘要：

  The present invention relates to a genetic probe comprising: a nanoparticle; an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker; wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker. The invention also relates to a composition or kit containing a probe of the invention.

  公开号：

  US12043865B2
• 作为产物：
  描述：

  蒽酮 、 溴乙酸乙酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以35%的产率得到ethyl 9-anthryloxyacetate
  参考文献：
  名称：

  Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe

  摘要：

  一种新型蒽标记寡核苷酸可通过双链形成时荧光发射强度的显著差异，区分完全匹配的 DNA 目标序列和含有单个错配碱基对的目标序列。

  DOI：

  10.1039/b611650g

文献信息

• Structural Effects on the Ground and Excited-state Properties of Photoswitchable Hydrogen-Bonding Receptors
  作者：Yann Molard、Dario M. Bassani、Jean-Pierre Desvergne、Nina Moran、James H. R. Tucker

  DOI：10.1021/jo061528a

  日期：2006.10.1

  via (CH2)n (n = 1, 3−6) polymethylene linkers to the H-bond receptor moiety, are described. In these systems, the thermally reversible [4π + 4π] photodimerization of the anthracenes yields macrocyclic receptors (TnC) that possess significantly reduced affinity toward barbital as compared to their acyclic counterparts. The length of the tether not only determines the overall binding ability of the cyclized

  一系列光致变色巴比妥酸酯受体（N，N'-双6- [ω-（蒽-9-烷氧基）烷酰基氨基]吡啶基-2-基} -5-叔丁基-描述了间苯二甲酰胺T n，其中蒽发色团通过（CH 2）n（n = 1，3-6）聚亚甲基接头与H键受体部分相连。在这些系统中，蒽的热可逆[4π+4π]光二聚产生大环受体（T n C）与无环同类物相比，对巴比妥的亲和力大大降低。系链的长度不仅决定了环化受体的整体结合能力，而且对蒽发色团的光化学和光物理性质产生了深远的影响。共价结合的蒽所经历的降低的迁移率控制了荧光准分子的反应性，该准分子被认​​为是光环化过程的中间体。
• Photoinduced Formation of a Cryptand from a Coronand: An Unexpected Switch in Cation Binding Affinity
  作者：Gordon McSkimming、James H. R. Tucker、Henri Bouas-Laurent、Jean-Pierre Desvergne、Simon J. Coles、Michael B. Hursthouse、Mark E. Light

  DOI：10.1002/1521-3765(20020802)8:15<3331::aid-chem3331>3.0.co;2-c

  日期：2002.8.2

  Aza-crown ethers 2 and 3 with anthracene-containing pendant arms have been synthesised and characterised. Both compounds bind Group 1 metal cations in solution, forming complexes of 1:1 stoichiometry. The properties of compound 2 and its complexes have been studied by a range of techniques,. including NMR, UV and fluorescence spectroscopy and X-ray crystallography. The pendant arms can adopt either a cis or a trans geometry, the cis geometry favoured with larger cations. The geometry of the complex affects the fluorescence properties of the system, with larger cations giving higher excimer/monomer ratios. Upon irradiation lambda > 300 nm, coronand 2 forms the cryptand 5 through a reversible intramolecular [4pi+4pi] cycloaddition reaction. The rates of the forward and reverse reactions of this photochromic process are cation dependent; in particular the rate of the thermal reverse reaction is decreased by smaller cations and increased by larger cations, especially Rb+. The metal binding constants in methanol for 2 and 5 have been determined, revealing that the cryptand 5 binds Na+ and Rb+ more weakly than crown ether 2 by over two orders of magnitude.
• SENSOR
  申请人：The University of Birmingham

  公开号：US20200332349A1

  公开（公告）日：2020-10-22

  The present invention relates to a genetic probe for the detection of a single nucleotide polymorphism (SNP) or a single nucleotide modification of a target nucleic acid, the genetic probe comprising: —a nanoparticle; —an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and —a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker; wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker. The invention also relates to a composition or kit containing a probe of the invention, or to the use of a probe of the invention. The invention also relates to a method of determining the percentage of single nucleotide polymorphisms (SNPs) or single nucleotide modifications of a target nucleic acid in a pool of the target nucleic acid, or to a method of determining the status of a condition associated with a known SNP in a subject
• [EN] SENSOR<br/>[FR] CAPTEUR
  申请人：UNIV BIRMINGHAM

  公开号：WO2019043353A1

  公开（公告）日：2019-03-07

  The present invention relates to a genetic probe for the detection of a single nucleotide polymorphism (SNP) or a single nucleotide modification of a target nucleic acid, the genetic probe comprising: -a nanoparticle; -an oligonucleotide probe anchored to the surface of the nanoparticle, comprising an oligonucleotide backbone with a tag incorporated therein via a linker group; and -a reference probe anchored to the surface of the nanoparticle, wherein the reference probe comprises a marker; wherein either (a) the tag is an organic fluorescent tag and the marker is a transition metal-based fluorescent marker; or (b) the tag is a redox-active tag and the marker is a transition metal-based redox-active marker.The invention also relates to a composition or kit containing a probe of the invention, or to the use of a probe of the invention. The invention also relates to a method of determining the percentage of single nucleotide polymorphisms (SNPs) or single nucleotide modifications of a target nucleic acid in a pool of the target nucleic acid, or to a method of determining the status of a condition associated with a known SNP in a subject