Glycolate-Phenylalanine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Glycolate-Phenylalanine
• 英文别名: 2-[(2-hydroxyacetyl)amino]-3-phenylpropanoic acid
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.22
• InChiKey: NDOMNCKCNVGBNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 1,5-Benzothiazepines and their use as hypolipidaemics
  申请人：——

  公开号：US20030166927A1

  公开（公告）日：2003-09-04

  The present invention relates to compounds of formula (I) wherein R 1 and R 2 are independently selected from C 1-6 alkyl; one of R 4 and R 5 is a group of formula (IA): R 3 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 and the other of R 4 and R 5 are as defined within, pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and there use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

  本发明涉及式（I）的化合物，其中R1和R2分别选自C1-6烷基；R4和R5中的一个是式（IA）的基团：R3、R6、R7、R8、R9、R10和R11，另一个是如下定义的基团，其药学上可接受的盐、溶剂化合物、该类盐的溶剂化合物和它们的前药，以及它们作为远端胆酸转运（IBAT）抑制剂用于治疗高脂血症。还描述了它们的制备方法和含有它们的药物组合物。
• AQEOUS COMPOSITION COMPRISING AT LEAST ONE PROTEIN AND ONE SOLUBILIZING AGENT, PREPARATION THEREOF AND USES THEREOF
  申请人：ADOCIA

  公开号：US20150335751A1

  公开（公告）日：2015-11-26

  A liquid composition which has, in an aqueous medium, one or more protein(s) and one or more solubilizing agent(s) chosen from anionic compounds of non-saccharide structure, the structure of which contains at least one aromatic nucleus having at least 6 ring members and at least one carboxylic acid group in salified form, and which has, in its acid form, a molar mass between 130 and 500 g/mol. A process for solubilizing one or more protein(s), wherein at least one solubilizing agent chosen from anionic compounds of non-saccharide structure, the structure of which contains at least one aromatic nucleus having at least 6 ring members and at least one carboxylic acid group in salified form, and which has, in its acid form, a molar mass between 130 and 500 g/mol, is added to an aqueous protein preparation in order to solubilize the protein is also provided.

  一种液态组合物，其中在水介质中含有一种或多种蛋白质和一种或多种溶解剂，所述溶解剂选择非糖结构的阴离子化合物，其结构中含有至少一个芳香核，该核至少有6个环成员，以及至少一个酸基盐形式，其酸性形式的摩尔质量在130至500克/摩尔之间。还提供了一种溶解一种或多种蛋白质的方法，其中至少添加一种溶解剂，所述溶解剂选择非糖结构的阴离子化合物，其结构中含有至少一个芳香核，该核至少有6个环成员，以及至少一个酸基盐形式，其酸性形式的摩尔质量在130至500克/摩尔之间，以便溶解蛋白质。
• 1,5-BENZOTHIAZEPINES AND THEIR USE AS HYPOLIPIDAEMICS
  申请人：AstraZeneca AB

  公开号：EP1263747A1

  公开（公告）日：2002-12-11
• AQUEOUS COMPOSITION COMPRISING AT LEAST ONE PROTEIN AND ONE SOLUBILIZING AGENT, PREPARATION THEREOF AND USES THEREOF
  申请人：ADOCIA

  公开号：US20180214556A1

  公开（公告）日：2018-08-02

  The present invention relates to a liquid composition which comprises, in an aqueous medium, one or more protein(s) and one or more solubilizing agent(s) chosen from the group consisting of anionic compounds of non-saccharide structure, said structure of which contains at least one aromatic nucleus comprising at least 6 ring members (6 atoms) and at least one carboxylic acid group in salified form, and which has, in its acid form, a molar mass of between 130 and 500 g/mol. It also relates to the use of said solubilizing agent(s) for preparing compositions according to the invention. It also relates to a process for solubilizing one or more protein(s), wherein at least one solubilizing agent chosen from the group consisting of anionic compounds of non-saccharide structure, said structure of which contains at least one aromatic nucleus comprising at least 6 ring members (6 atoms) and at least one carboxylic acid group in salified form, and which has, in its acid form, a molar mass of between 130 and 500 g/mol, is added to an aqueous protein preparation in order to solubilize the protein.
• US6906058B2
  申请人：——

  公开号：US6906058B2

  公开（公告）日：2005-06-14