[Pt(ethylenediamine)((methylsulfanyl)acetato)]NO3 | 162048-52-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Pt(ethylenediamine)((methylsulfanyl)acetato)]NO3
• 英文别名: [Pt(en)((methylsulfanyl)acetate-O,S)]NO3
• CAS: 162048-52-4
• 化学式: C₅H₁₃N₂O₂PtS*NO₃
• 分子量: 422.321
• InChiKey: BXCBJSSEHIVMMB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pt(ethylenediamine)((methylsulfanyl)acetato)]NO3 、 (甲硫基)乙酸 在 氢氧化钾 作用下， 以 水 为溶剂， 以75%的产率得到(ethane-1,2-diamine)bis(methylsulfanylacetato-S)platinum(II)
  参考文献：
  名称：

  Pasini, Alessandro; Moroni, Maurizio, Journal of the Chemical Society, Dalton Transactions, 1997, # 6, p. 1093 - 1097

  摘要：

  DOI：
• 作为产物：
  描述：

  ethylenediamine platinum(II) nitrate 、 (methylsulfanyl)acetic acid potassium salt 以 水 为溶剂， 生成 [Pt(ethylenediamine)((methylsulfanyl)acetato)]NO3
  参考文献：
  名称：

  Cisplatin analogues with sulfur donor ligands. (Ethylenediamine)platinum(II) complexes with ligands possessing a sulfinyl or sulfanyl group linked to an anionic oxygen donor atom. Reactivity and cytotoxicity

  摘要：

  Complexes of formula [Pt(en)L]NO3, where en = ethylenediamine and L is a ligand in which a methylsulfinyl or methylsulfanyl group is linked to a carboxylate or phenolate moiety, have been synthesized and characterized by spectroscopic techniques. The ligand L is chelated to Pt via the sulfur and anionic oxygen atoms. The reactivities of these complexes towards nucleophiles [Nu = Cl- or guanosine 5'-monophosphate(2-), GMP] have been investigated by H-1 NMR spectroscopy; GMP is more reactive than Cl-. The Pt-O bonds react more readily than the Pt-S bonds and, depending on the nature of L and Nu, the reactions either stop at the monosubstituted complex [Pt(en)L(Nu)] (with L monodentate and co-ordinated to Pt via the sulfur atom), or yield [Pt(en)(Nu)2]. The complex with L = 2-(methylsulfanyl)phenolate is unreactive. The stable monosubstituted products have been characterized. There is little correlation between the rates and the modes of reactivity of complexes [Pt(en)L]NO3 towards GMP and their cytotoxicities against the human ovarian carcinoma A2780 cell line.

  DOI：

  10.1039/dt9950000579

文献信息

• Antisymbiosis. Preferential coordination of anionic oxygen versus neutral sulfur donor atoms of methylsulfanyl- or methylsulfinyl-acetato, 2-benzoato and 2-phenolato to the cis-PtII(PPh3)2 and PtII(dppe) residues
  作者：Laura Battan、Serena Fantasia、Mario Manassero、Alessandro Pasini、Mirella Sansoni

  DOI：10.1016/j.ica.2004.09.039

  日期：2005.2

  tetramethylthiourea. Substitution of L’s occurs with N,N′-diethyldithiocarbamate, which forms a very stable chelate with Pt(II). Thiourea and N,N′-dimethylthiourea also react, because they give rise to cyclometallated products [Pt(phos)2(NRC(S)NHR)]+ (R = H, CH3), with one ionised thioamido group, as revealed by an X-ray investigation of [Pt(PPh3)2(NHC(S)NH2)]+. The preference of O versus S coordination, as well as

  过量的标题的相互作用配体L -与顺式-PT（PHOS）2个部分得到化合物一- b顺- [铂（L- ø）2（膦）2 ]（一，PHOS = P（PH）3 ; b，phOS = 1/2 dppe），其中O-优于S-配位。这样的偏好是由相同的产品是由的过量的L-的反应获得的事实证实-与以前报道的一- d络合物[PT（L- O，S）（膦）2] +，（c，phOS = PPh 3，d，phOS = 1/2 dppe），由于PT–S而不是PT–O键断裂，螯合物开环发生。化合物a也可以通过将HL氧化加成到[PT（PPh 3）3 ]中而获得。化合物a - d中的PT-O键对于被Me 2 SO，吡啶和四甲基硫脲取代是稳定的。N，N'-二乙基二硫代氨基甲酸酯会取代L's ，后者与PT（II）形成非常稳定的螯合物。硫脲和N，N′-二甲基硫脲也会发生反应，因为它们会产生一个环化金属化产物[PT（phOS）2（N RC（S）NHR）]