3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-(2-methylpropyl)-2-oxo-1-pyrrolidineacetamide | 501380-92-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-(2-methylpropyl)-2-oxo-1-pyrrolidineacetamide
• CAS: 501380-92-3
• 化学式: C₂₀H₃₄N₄O₅
• 分子量: 410.514
• InChiKey: AWYATYTZUVJRFT-XOBRGWDASA-N

物化性质

• 沸点：
  656.2±55.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  三氟乙酸 、 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-(2-methylpropyl)-2-oxo-1-pyrrolidineacetamide 以 二氯甲烷 为溶剂， 以55%的产率得到3(R)-[[[2(S)-pyrrolidinyl]carbonyl]amino]-3-(2-methylpropyl)-2-oxo-1-pyrrolidineacetamide trifluoroacetate
  参考文献：
  名称：

  Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide

  摘要：

  gamma-Lactam. peptidomimetic 2 of Pro-Leu-Gly-NH2 (PLG) was substituted at the 3-position with isobutyl, butyl, and benzyl moieties to give the PLG peptidomimetics 3-5, respectively. These compounds were synthesized to test the hypothesis that attaching a hydrophobic moiety to the lactam ring to mimic the isobutyl side chain of the leucyl residue of PLG would increase the dopamine receptor modulating activity of such peptidomimetics. These peptidomimetics were tested for their ability to enhance the binding of [H-3]-N-propylnorapomorphine to dopamine receptors isolated from bovine striatal membranes. The rank order of effectiveness of the 3-substituent was benzyl > n-butyl > isobutyl > H.

  DOI：

  10.1021/jm020441o
• 作为产物：
  描述：

  methyl 3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-(2-methylpropyl)-2-oxo-1-pyrrolidineacetate 在 氨 作用下， 以51%的产率得到3(R)-[[[1-(tert-butoxycarbonyl)-2(S)-pyrrolidinyl]carbonyl]amino]-3-(2-methylpropyl)-2-oxo-1-pyrrolidineacetamide
  参考文献：
  名称：

  Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide

  摘要：

  gamma-Lactam. peptidomimetic 2 of Pro-Leu-Gly-NH2 (PLG) was substituted at the 3-position with isobutyl, butyl, and benzyl moieties to give the PLG peptidomimetics 3-5, respectively. These compounds were synthesized to test the hypothesis that attaching a hydrophobic moiety to the lactam ring to mimic the isobutyl side chain of the leucyl residue of PLG would increase the dopamine receptor modulating activity of such peptidomimetics. These peptidomimetics were tested for their ability to enhance the binding of [H-3]-N-propylnorapomorphine to dopamine receptors isolated from bovine striatal membranes. The rank order of effectiveness of the 3-substituent was benzyl > n-butyl > isobutyl > H.

  DOI：

  10.1021/jm020441o