3-(2-Acetoxyethyl)-2,4-dimethylpyrrol-5-carbonsaeure | 52090-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(2-Acetoxyethyl)-2,4-dimethylpyrrol-5-carbonsaeure
• 英文别名: 4-(2-acetoxy-ethyl)-3,5-dimethyl-pyrrole-2-carboxylic acid；4-[2-(Acetyloxy)ethyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid；4-(2-acetyloxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
• CAS: 52090-96-7
• 化学式: C₁₁H₁₅NO₄
• 分子量: 225.244
• InChiKey: DKDHNFXHSHRMBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  79.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1218373A2

  公开（公告）日：2002-07-03
• US7060822B1
  申请人：——

  公开号：US7060822B1

  公开（公告）日：2006-06-13
• [EN] 2-PYRAZOLIN-5-ONES<br/>[FR] 2-PYRAZOLIN-5-ONES
  申请人：BASF AG

  公开号：WO2001009121A2

  公开（公告）日：2001-02-08

  Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.