硫辛酰氨基-PEG12-羧酸 | 2407442-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 中文名称: 硫辛酰氨基-PEG12-羧酸
• 英文名称: Lipoamido-PEG12-acid
• 英文别名: 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[5-(dithiolan-3-yl)pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• CAS: 2407442-47-9
• 化学式: C₃₅H₆₇NO₁₅S₂
• 分子量: 806.0
• InChiKey: KTDABPXYRAJNFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  53
• 可旋转键数：
  44
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  228
• 氢给体数：
  2
• 氢受体数：
  17

文献信息

• METHODS FOR SELECTING ENZYMES HAVING ENHANCED ACTIVITY
  申请人：NOVOZYMES A/S

  公开号：US20180073017A1

  公开（公告）日：2018-03-15

  Provided herein are methods and means for enhancing enzymatic activity. The system makes use of an emulsion for in vitro compartmentalization of a library of synthetic compounds which have a gene and a marked enzymatic substrate both directly linked to a solid phase. Expressed enzymes with greater activity will preferentially release the selectable marker from the solid phase, whereas enzymes with less activity will leave the markers intact. Removal of the marked compounds provides an enriched gene library encoding for more active variants. Also described are synthetic compounds and emulsions which can be used in the methods.