2,4-di-tert-butyl-6-(iminomethyl)phenol | 106897-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-di-tert-butyl-6-(iminomethyl)phenol
• 英文别名: 2,4-Di-t-butyl-6-(iminomethyl)phenol；2,4-ditert-butyl-6-methanimidoylphenol
• CAS: 106897-54-5
• 化学式: C₁₅H₂₃NO
• 分子量: 233.354
• InChiKey: FPWFKMNXNJXCPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,5-二叔丁基水杨醛 、 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 12.0h， 以11%的产率得到(1S,2S,4S,E)-N-(2-hydroxy-3,5-di-tert-butylbenzylidene)-1,7,7-trimethylbicyclo[2.2.1]-heptane-2-sulfenamide
  参考文献：
  名称：

  Synthesis and reduction of new sulfinimines with isobornane structure

  摘要：

  Synthesis of sulfenimines proceeding from isobornanethiol with yields up to 78% was performed. They were oxidized to diastereomeric isobornylsulfinimines and the latter were reduced to N-substituted isobornylsulfinamides in high yields.

  DOI：

  10.1134/s1070428012110024

文献信息

• [EN] A GLUCOPYRANOSYL DERIVATIVE AND PREPARATION METHOD AND USES THEREOF<br/>[FR] DÉRIVÉ DE GLUCOPYRANOSYLE, SON PROCÉDÉ DE PRÉPARATION ET SES UTILISATIONS
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2016173425A1

  公开（公告）日：2016-11-03

  This present invention relates to a glucopyranosyl derivative as sodium dependent glucose cotransporters (SGLTs) inhibitor, preparation processes thereof, and pharmaceutical uses thereof, pharmaceutical compositions containing the compound and their uses for treating diabetes and diabetes-related diseases. The process of the invention has simple operation, high optical purity of product, high yield and convenient work-up, easy purification, and is suitable for industrial production.

  本发明涉及一种葡萄糖吡喃糖苷衍生物，作为钠依赖型葡萄糖共转运蛋白（SGLTs）抑制剂，以及其制备方法、药用用途，包含该化合物的药用组合物及其用于治疗糖尿病和糖尿病相关疾病的用途。该发明的制备过程操作简单，产品光学纯度高，产率高，操作方便，易于纯化，并适用于工业生产。
• [EN] METHOD FOR PREPARING GLUCOPYRANOSYL DERIVATIVES AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE GLUCOPYRANOSYLE ET INTERMÉDIAIRES DE CEUX-CI
  申请人：DONGGUAN HEC NEW DRUG R & D CO LTD

  公开号：WO2022007838A1

  公开（公告）日：2022-01-13

  A method for preparing glucopyranosyl derivatives as sodium dependent glucose cotransporter (SGLT) inhibitors, an intermediate thereof, and a method for preparing the intermediate. The method has simple operation, simple post-treatment, easy purification, high total yield, high optical purity of the product, safe and controllable process, and is suitable for industrial production.

  一种制备葡萄糖吡喃基衍生物作为钠依赖型葡萄糖共转运蛋白（SGLT）抑制剂的方法，其中间体，以及制备该中间体的方法。该方法操作简单，后处理简单，易于纯化，总产率高，产品光学纯度高，过程安全可控，适合工业生产。
• SELECTIVE APOPTOTIC INDUCTION IN CANCER CELLS INCLUDING ACTIVATION OF PROCASPASE-3
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：EP1893210B1

  公开（公告）日：2019-10-02
• MACROCYCLICS PYRIMIDINES AS AURORA KINASE INHIBITORS
  申请人：Merck Serono SA

  公开号：EP2334301B1

  公开（公告）日：2018-02-14
• [EN] EPOXY RESIN PRODUCTION<br/>[FR] PRODUCTION DE RÉSINE ÉPOXY
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2010099295A1

  公开（公告）日：2010-09-02

  A process comprising contacting a polyhydric phenol or a polyaliphatic alcohol with an epihalohydrin in the presence of a catalyst comprising a Schiff base metal complex is disclosed.