S-(m-Trifluormethylbenzyl)-ethylenthioharnstoff | 60890-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-(m-Trifluormethylbenzyl)-ethylenthioharnstoff
• 英文别名: 2-(3-trifluoromethyl-benzylsulfanyl)-4,5-dihydro-1H-imidazole；2-({[3-(Trifluoromethyl)phenyl]methyl}sulfanyl)-4,5-dihydro-1H-imidazole；2-[[3-(trifluoromethyl)phenyl]methylsulfanyl]-4,5-dihydro-1H-imidazole
• CAS: 60890-22-4
• 化学式: C₁₁H₁₁F₃N₂S
• 分子量: 260.283
• InChiKey: RWOKOOCWYMAYNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS
  申请人：Aventis Pharmaceuticals, Inc.

  公开号：EP1651613A1

  公开（公告）日：2006-05-03
• [EN] 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS<br/>[FR] 4,5-DIHYDRO-IMIDAZOLE UTILISE COMME ANTAGONISTES DES CANAUX IONIQUES P2X7
  申请人：AVENTIS PHARMA INC

  公开号：WO2005014555A1

  公开（公告）日：2005-02-17

  The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula (II): wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.