N,N'-dibenzylethyleneamine | 152494-03-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-dibenzylethyleneamine
• 英文别名: N,N'-dibenzylethylenamine；N,N-dibenzylethenamine
• CAS: 152494-03-6
• 化学式: C₁₆H₁₇N
• 分子量: 223.318
• InChiKey: KQDHXLHIQQGOCF-UHFFFAOYSA-N

物化性质

• 沸点：
  361.0±31.0 °C(Predicted)
• 密度：
  1.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N'-dibenzylethyleneamine 在 硼烷四氢呋喃络合物 、 双氧水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 24.0h， 以0.181 g的产率得到N,N-二苄基乙醇胺
  参考文献：
  名称：

  Catalytic Reductive Dehydration of Tertiary Amides to Enamines under Hydrosilylation Conditions

  摘要：

  Tertiary amides are efficiently reduced to their corresponding enamines under hydrosilylation conditions, using a transition-metal-free catalytic protocol based on t-BuOK (5 mol %) and (MeO)(3)SiH or (EtO)(3)SiH as the reducing agent. The enamines were formed with high selectivity in good-to-excellent yields.

  DOI：

  10.1021/ol403302g
• 作为产物：
  描述：

  N,N-二苄基-乙酰胺 在 三甲氧基硅烷 、 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 N,N'-dibenzylethyleneamine
  参考文献：
  名称：

  Catalytic Reductive Dehydration of Tertiary Amides to Enamines under Hydrosilylation Conditions

  摘要：

  Tertiary amides are efficiently reduced to their corresponding enamines under hydrosilylation conditions, using a transition-metal-free catalytic protocol based on t-BuOK (5 mol %) and (MeO)(3)SiH or (EtO)(3)SiH as the reducing agent. The enamines were formed with high selectivity in good-to-excellent yields.

  DOI：

  10.1021/ol403302g

文献信息

• NHC/Nickel(II)‐Catalyzed [3+2] Cross‐Dimerization of Unactivated Olefins and Methylenecyclopropanes
  作者：Jian‐Qiang Huang、Chun‐Yu Ho

  DOI：10.1002/anie.201914542

  日期：2020.3.23

  typical hydroalkenylation reactivity was observed for the first time by using a [NHC-Ni(allyl)]BArF catalyst (NHC=N-heterocyclic carbene). Results show that the C-C cleavage of 1 did not involve a Ni0 oxidative addition, which was crucial in former systems. Thus the method reported here emerges as a complementary method for attaining highly chemo- and regioselective synthesis of methylenecyclopentanes

  通过使用[NHC-Ni（烯丙基）] BArF催化剂（NHC = N-杂环卡宾）首次观察到具有典型的加氢烯基化反应活性的亚甲基环丙烷（1）和未活化的烯烃（2）的交叉二聚。结果表明，CC裂解1不涉及Ni0氧化加成，这在以前的系统中至关重要。因此，这里报道的方法作为获得高度化学和区域选择性的亚甲基环戊烷（3）的广泛方法的补充方法而出现。1在NHC / NiII催化下的有效重排导致2的存在下3的收敛合成。
• AGRICULTURAL PLANT-PROTECTING AGENTS CONTAINING DIPEPTIDE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：REPUBLIC OF KOREA (RURAL DEVELOPMENT ADMINISTRATION)

  公开号：US20150119251A1

  公开（公告）日：2015-04-30

  Provided is an agricultural plant-protecting agent including a dipeptide derivative or an agro-pharmaceutically acceptable salt thereof as an active ingredient, which has a plant disease-preventing effect, a plant growth-promoting effect, and a plant immunity-activating effect.

  提供了一种农业植物保护剂，其中包括二肽衍生物或其农药学上可接受的盐作为活性成分，具有预防植物病害、促进植物生长和激活植物免疫的效果。
• [EN] POLY(ETHYLENE GLYCOL) DERIVATIVES FOR METAL-FREE CLICK CHEMISTRY<br/>[FR] DÉRIVÉS DE POLY(ÉTHYLÈNEGLYCOL) POUR CHIMIE CLICK SANS MÉTAL
  申请人：INTEZYNE TECHNOLOGIES INC

  公开号：WO2011112969A1

  公开（公告）日：2011-09-15

  The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

  本发明提供了双功能聚合物、其制备方法和中间体。这些化合物可用于多种应用，包括对生物活性分子进行PEG化。本发明还提供了使用上述化合物和其组成物的方法。
• Method of inhibiting neoplastic cells with indole derivatives
  申请人：——

  公开号：US20020143022A1

  公开（公告）日：2002-10-03

  A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.

  通过将替代吲哚衍生物暴露给肿瘤细胞及其相关情况，抑制其生长的方法。
• KIT FOR PRODUCING MOLECULAR PROBE FOR PET SCREENING FOR DRUG DISCOVERY
  申请人：Doi Hisashi

  公开号：US20110064662A1

  公开（公告）日：2011-03-17

  Disclosed is a kit for use in the production of a molecular probe for PET drug screening for the purpose of producing a compound containing a short-lived radionuclide for PET applications. Specifically disclosed is a kit comprising a compound represented by the formula (I), (II) or (III) or a salt thereof. In the formulae, X 1 , X 2 , X 3 , X 4 , X 5 and X 6 are as defined in the description.

  本发明揭示了一种用于制备PET药物筛选分子探针的试剂盒，其目的是为了生产含有短寿命放射性核素的化合物，以供PET应用。具体揭示的是一种试剂盒，包括公式（I），（II）或（III）或其盐所表示的化合物。在这些公式中，X1，X2，X3，X4，X5和X6如描述中所定义。