2-Methyl-3-(4-pyridyl)-alanin | 70258-06-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Methyl-3-(4-pyridyl)-alanin
• 英文别名: 2-amino-2-methyl-3-pyridin-4-yl-propionic acid；2-Amino-2-methyl-3-(pyridin-4-yl)propanoic acid；2-amino-2-methyl-3-pyridin-4-ylpropanoic acid
• CAS: 70258-06-9
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: FYXUEVYRXPRJQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-Methyl-3-(4-pyridin-N-oxid)-alanin 以91%的产率得到
  参考文献：
  名称：

  TILLEY J. W.; LEVITAN P.; KIERSTEAD R. W., J. HETEROCYCL. CHEM., 1979, 16, NO 2, 333-337

  摘要：

  DOI：

文献信息

• [EN] 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] COMPOSES DERIVES DE PYRIDYLE SUBSTITUES AUX POSITIONS 2, 4, 6 UTILES COMME INHIBITEURS DE LA BETA-SECRETASE DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2005103043A1

  公开（公告）日：2005-11-03

  The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer’s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及2,4,6-取代吡啶衍生物化合物，这些化合物是β-分泌酶的抑制剂，可用于治疗涉及β-分泌酶的疾病，如阿尔茨海默病。该发明还涉及包含这些化合物的药物组合物以及在治疗涉及β-分泌酶的疾病中使用这些化合物和组合物。
• 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1740581B1

  公开（公告）日：2012-08-22
• [EN] 2,3,4,6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] DERIVES PYRIDYLE 2,3,4,6-SUBSTITUES UTILES COMME INHIBITEURS DE LA BETA-SECRETASE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2006057945A2

  公开（公告）日：2006-06-01

  [EN] The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
  [FR] La présente invention concerne des dérivés pyridyle 2,3,4,6-substitués qui sont des inhibiteurs de l'enzyme bêta-secrétase et qui sont utiles dans le traitement de maladies dans lesquelles l'enzyme bêta-secrétase est impliquée, telles que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés et de ces compositions dans le traitement de maladies dans lesquelles l'enzyme bêta-secrétase est impliquée.