7-Hex-5-enyloxy-chromen-2-one | 262448-05-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-Hex-5-enyloxy-chromen-2-one
• 英文别名: 7-Hex-5-enoxychromen-2-one
• CAS: 262448-05-5
• 化学式: C₁₅H₁₆O₃
• 分子量: 244.29
• InChiKey: AEPAGIBFEYSJTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Hex-5-enyloxy-chromen-2-one 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 水 、 丙酮 、 叔丁醇 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Enzyme Activity Fingerprinting with Substrate Cocktails

  摘要：

  In the postgenomic era, emphasis is shifting from protein identification to protein functional analysis. Enzyme function can be characterized by measuring activity across series of substrates, which generates an activity profile or fingerprint. Activity fingerprinting is particularly useful to differentiate closely related enzymes. Previously reported fingerprinting methods use series of parallel measurements, which are complex and difficult to reproduce. Here we report a new method for fingerprinting enzyme activities based on using mixtures of substrates, or substrate cocktails, in a single reaction that is then analyzed by HPLC. The fingerprints produced are highly reproducible and allow functional differentiation and classification of closely related enzymes, as demonstrated for a series of lipases and esterases. The method is practical, general, and flexible in terms of reaction conditions and can be adapted to any reaction type.

  DOI：

  10.1021/ja0478330
• 作为产物：
  描述：

  7-羟基香豆素 、 6-溴-1-己烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 5.0h， 生成 7-Hex-5-enyloxy-chromen-2-one
  参考文献：
  名称：

  Enzyme Activity Fingerprinting with Substrate Cocktails

  摘要：

  In the postgenomic era, emphasis is shifting from protein identification to protein functional analysis. Enzyme function can be characterized by measuring activity across series of substrates, which generates an activity profile or fingerprint. Activity fingerprinting is particularly useful to differentiate closely related enzymes. Previously reported fingerprinting methods use series of parallel measurements, which are complex and difficult to reproduce. Here we report a new method for fingerprinting enzyme activities based on using mixtures of substrates, or substrate cocktails, in a single reaction that is then analyzed by HPLC. The fingerprints produced are highly reproducible and allow functional differentiation and classification of closely related enzymes, as demonstrated for a series of lipases and esterases. The method is practical, general, and flexible in terms of reaction conditions and can be adapted to any reaction type.

  DOI：

  10.1021/ja0478330

文献信息

• Cobalt-Catalyzed Multicomponent Carbonylation of Olefins: Efficient Synthesis of β-Perfluoroalkyl Imides, Amides, and Esters
  作者：Yaxin Wang、Peng Wang、Helfried Neumann、Matthias Beller

  DOI：10.1021/acscatal.3c00771

  日期：2023.5.19

  multicomponent 1,2-perfluoroalkylation carbonylation of alkenes has been developed. This protocol allows the synthesis of β-perfluoroalkyl-substituted amides, esters, and related derivatives using olefins, carbon monoxide, commercially accessible perfluoroalkyl iodides, and a variety of nucleophiles including low nucleophilic amides and urea derivatives in a one-pot manner. As an example, readily available

  已经开发了一种通用且广泛适用的钴催化的烯烃多组分 1,2-全氟烷基化羰基化反应。该协议允许使用烯烃、一氧化碳、市售全氟烷基碘化物和各种亲核试剂（包括低亲核酰胺和尿素衍生物）以一锅方式合成 β-全氟烷基取代的酰胺、酯和相关衍生物。例如，可以利用现成的三氟碘甲烷形成药学相关的 β-三氟甲基化酰胺。为了展示应用潜力，将全氟烷基化羰基化工艺应用于选定的现有药物和生物活性分子。
• Compounds containing Si atoms for optically active devices
  申请人：Merck Patent GmbH

  公开号：US11040990B2

  公开（公告）日：2021-06-22

  The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

  本发明涉及新型化合物，特别是包含光活性单元的化合物，所述新型化合物尤其适用于组合物和眼科设备，以及包含此类化合物的组合物和眼科设备。
• COMPOUNDS CONTAINING SI ATOMS FOR OPTICALLY ACTIVE DEVICES
  申请人：Merck Patent GmbH

  公开号：EP3583100B1

  公开（公告）日：2021-05-05