N-(2,4-dimethylphenyl)methacrylamide | 29639-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,4-dimethylphenyl)methacrylamide
• 英文别名: methacrylic acid-(2,4-dimethyl-anilide)；Methacrylsaeure-(2,4-dimethyl-anilid)；N-(2,4-dimethylphenyl)-2-methylprop-2-enamide
• CAS: 29639-60-9
• 化学式: C₁₂H₁₅NO
• mdl: MFCD24389920
• 分子量: 189.257
• InChiKey: NUWSUHJTDXMVKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(2,4-dimethylphenyl)methacrylamide 在 四甲基乙二胺 、 sodium hydride 、 copper(I) bromide 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 18.0h， 生成 ethyl 2,2-dimethyl-3-(1,3,5,7-tetramethyl-2-oxoindolin-3-yl)propanoate
  参考文献：
  名称：

  N-苯基丙烯酰胺与2-溴-2-甲基丙酸乙酯之间的铜介导反应合成羟吲哚

  摘要：

  已经描述了通过N-苯基丙烯酰胺和2-溴-2-甲基丙酸乙酯之间的Cu介导的原子转移自由基加成反应合成烷基化的吲哚的新方法。发现使用N，N，N '，N'-1,1,2,2，-四甲基乙二胺作为配体对于获得良好的收率很重要。此外，使用DMSO作为溶剂并在130°C下进行反应也很关键。在某些情况下，当反应温度升至150°C时，产品可以进一步溴化。

  DOI：

  10.1016/j.tetlet.2017.12.053
• 作为产物：
  描述：

  2,4-二甲基苯胺 在 乙基溴化镁 作用下， 生成 N-(2,4-dimethylphenyl)methacrylamide
  参考文献：
  名称：

  Bieber, Bulletin de la Societe Chimique de France, 1954, p. 56

  摘要：

  DOI：

文献信息

• Bromo Radical‐Mediated Photoredox Aldehyde Decarbonylation towards Transition‐Metal‐Free Hydroalkylation of Acrylamides at Room Temperature
  作者：Zhaozhao Sun、Huawen Huang、Qiaolin Wang、Guo‐Jun Deng

  DOI：10.1002/adsc.202101188

  日期：2022.1.18

  Herein, we report a visible-light-mediated hydroalkylation reaction of alkenes using easily available aldehydes as alkyl sources via bromo radical-promoted photoredox decarbonylation. This protocol provides an alternative entry to C(sp3)−C(sp3) bond formation and features considerable advantages including mild and clean reaction conditions, obviation for transition-metal catalyst, and good functional

  在这里，我们报告了一种可见光介导的烯烃加氢烷基化反应，使用容易获得的醛作为烷基源，通过溴自由基促进的光氧化还原脱羰。该协议为 C( sp 3 )-C( sp 3 ) 键的形成提供了一种替代方法，具有相当大的优势，包括温和和清洁的反应条件、无需过渡金属催化剂和良好的官能团相容性。
• Synthesis of Perfluoroalkyl-Substituted Oxindoles through Organophotoredox-Catalyzed Perfluoroalkylation of N-arylacrylamides with Perfluoroalkyl Iodides
  作者：Zhiyong Yang、Anjiang Tang

  DOI：10.1055/s-0037-1611781

  日期：2019.6

  An efficient process was developed for the perfluoroalkylation of N-arylacrylamides through an organocatalyzed photoredox/cyclization reaction of N-arylacrylamides with inexpensive perfluoroalkyl iodide reagents. The reaction employs an inexpensive organic dye, eosin Y, as the photoredox catalyst and is run under irradiation by a 26 W LED lightbulb.

  通过有机催化的光氧化还原/环化反应，开发了一种高效的过程，用于通过廉价的全氟烷基碘试剂对N-芳基丙烯酰胺进行全氟烷基化。该反应采用廉价的有机染料eosin Y作为光氧化还原催化剂，并在26瓦LED灯泡的照射下进行。
• Visible‐Light‐Induced Photoredox 1,1‐Dichloromethylation of Alkenes with Chloroform
  作者：Yingjie Cheng、Zhonghua Qu、Shiru Chen、Xiaochen Ji、Guo‐Jun Deng、Huawen Huang

  DOI：10.1002/adsc.202200074

  日期：2022.4.26

  A photoredox 1,1-dichloromethylation of alkenes with the readily available bulk chemical chloroform was described, furnishing a variety of 1,1-dichloroalkane products selectively. Furthermore, this transformation could proceed smoothly on gram-scale, and the obtained products could transform into diverse γ-lactam derivatives with simple treatment. Mechanistically, the single electron transfer (SET)

  描述了烯烃的光氧化还原 1,1-二氯甲基化与容易获得的散装化学氯仿，选择性地提供各种 1,1-二氯烷烃产品。此外，这种转化可以在克级上顺利进行，所得产物只需简单处理即可转化为多种γ-内酰胺衍生物。从机理上讲，激发光催化剂的单电子转移 (SET) 和随后的三乙胺去质子化生成关键的 α-氨基自由基中间体，从而实现氯仿的选择性 Cl 原子转移。特定的选择性、广泛的底物范围以及温和的反应条件使该策略特别有吸引力。
• THERMOPLASTIC RESIN COMPOSITION, OPTICAL FILM, AND PROCESS FOR PRODUCING FILM
  申请人：JSR Corporation

  公开号：EP1837374A1

  公开（公告）日：2007-09-26

  The present invention is intended to provide a thermoplastic resin composition which is inhibited from suffering phase separation and from which an optical film having excellent transparency is readily obtained, an optical film containing the composition as a main component, a retardation film which is a film obtained by stretching the optical film and exhibits positive wavelength dependence and has a small coefficient of photoelasticity and transparency, and a process for producing the retardation film. The thermoplastic resin composition contains (A) a cycloolefin-based polymer and (B) a vinyl-based polymer having a unit represented by the following formula (II): wherein at least one of R1 to R4 is a group represented by the formula (III), the remainder of R1 to R4, if any, and R5 and R6 are each a hydrogen atom, a halogen atom, a (substituted) hydrocarbon group which may have a linkage containing a hetero atom, or a polar group, R5 and R6 may be bonded to each other to form a monocyclic or polycyclic group which may have a hetero atom, or may be united to form a divalent hydrocarbon group, and Y is a divalent hydrocarbon group.

  本发明旨在提供一种热塑性树脂组合物，该组合物能抑制相分离，并能很容易地从中获得透明度极佳的光学薄膜；一种含有该组合物作为主要成分的光学薄膜；一种通过拉伸该光学薄膜而获得的延缓膜，该膜具有正波长依赖性，并具有较小的光弹性系数和透明度；以及一种生产该延缓膜的工艺。热塑性树脂组合物包含 (A) 环烯烃基聚合物和 (B) 乙烯基聚合物，其单元由下式 (II) 表示： 其中 R1 至 R4 中至少有一个是式(III)所代表的基团，R1 至 R4 的其余部分(如果有)以及 R5 和 R6 各为氢原子、卤素原子、(取代的)烃基(该烃基可能具有含杂原子的连接)或极性基团，R5 和 R6 可相互键合形成单环或多环基团，该单环或多环基团可能具有杂原子，或可结合形成二价烃基，Y 为二价烃基。
• Thermoplastic Resin Composition, Optical Film, And Process For Producing Film
  申请人：Miyaki Nobuyuki

  公开号：US20080177002A1

  公开（公告）日：2008-07-24

  The present invention is intended to provide a thermoplastic resin composition which is inhibited from suffering phase separation and from which an optical film having excellent transparency is readily obtained, an optical film containing the composition as a main component, a retardation film which is a film obtained by stretching the optical film and exhibits positive wavelength dependence and has a small coefficient of photoelasticity and transparency, and a process for producing the retardation film. The thermoplastic resin composition contains (A) a cycloolefin-based polymer and (B) a vinyl-based polymer having a unit represented by the following formula (II): wherein at least one of R 1 to R 4 is a group represented by the formula (III), the remainder of R 1 to R 4 if any, and R 5 and R 6 are each a hydrogen atom, a halogen atom, a substituted) hydrocarbon group which may have a linkage containing a hetero atom, or a polar group, R 5 and R 6 may be bonded to each other to form a monocyclic or polycyclic group which may have a hetero atom, or may be united to form a divalent hydrocarbon group and Y is a divalent hydrocarbon group.