(E)-2-(6-methoxyindan-1-ylidene)ethylamine hydrochloride | 187872-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (E)-2-(6-methoxyindan-1-ylidene)ethylamine hydrochloride
• 英文别名: (2E)-2-(6-methoxy-2,3-dihydroinden-1-ylidene)ethanamine;hydrochloride
• CAS: 187872-65-7
• 化学式: C₁₂H₁₅NO*ClH
• 分子量: 225.718
• InChiKey: CACYZIGKLNCXSM-AAGWESIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1199304A1

  公开（公告）日：2002-04-24

  A compound having the following general fomula: wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydrocarbon or heterocyclic group; X is CHR4, NR4, O or S in which R4 is H or an optionally substituted hydrocarbon group; R5 is H, a halogen atom, C1-6 alkyl group, a C1-6 alkoxy group, a hydroxy group, a nitro group, a cyano group or an amino group wherein the C1-6 alkyl group, the C1-6 alkoxy group and the amino group may be substituted by 1 to 5 substituents, Y is C or N; ring B is an optionally substituted benzene ring; m = 1 to 4 and n = 0 to 2; L represents a leaving group such as a halogen atom, an alkylsulfonyl group, an alkylsulfonlyoxy group and arylsulfonyloxy group; or a salt thereof.

  具有以下一般式的化合物： 其中R1是可选择取代的碳氢化合物、氨基或杂环基团；R2是H或可选择取代的碳氢基团；R3是H或可选择取代的碳氢基团或杂环基团；X是CHR4、NR4、O或S，其中R4是H或可选择取代的碳氢基团；R5是H、卤素原子、C1-6烷基基团、C1-6烷氧基团、羟基、硝基、氰基或氨基，其中C1-6烷基基团、C1-6烷氧基团和氨基可能被1至5个取代基取代，Y是C或N；环B是可选择取代的苯环；m = 1至4，n = 0至2；L代表离去基团，如卤素原子、烷基磺酰基团、烷基磺酰氧基团和芳基磺酰氧基团；或其盐。
• Bicyclic intermediates
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1550655A1

  公开（公告）日：2005-07-06

  A compound having the following general fomula: wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydrocarbon or heterocyclic group; X is CHR4, NR4, O or S in which R4 is H or an optionally substituted hydrocarbon group; R5 is H, a halogen atom, C1-6 alkyl group, a C1-6 alkoxy group, a hydroxy group, a nitro group, a cyano group or an amino group wherein the C1-6 alkyl group, the C1-6 alkoxy group and the amino group may be substituted by 1 to 5 substituents, Y is C or N; ring B is an optionally substituted benzene ring; m = 1 to 4 and n = 0 to 2; L represents a leaving group such as a halogen atom, an alkylsulfonyl group, an alkylsulfonlyoxy group and arylsulfonyloxy group; or a salt thereof.

  具有以下通式的化合物： 其中 R1 是任选取代的烃基、氨基或杂环基； R2 是 H 或任选取代的烃基； R3 是 H 或任选取代的烃基或杂环基； X 是 CHR4、NR4、O 或 S，其中 R4 是 H 或任选取代的烃基；R5 是 H、卤素原子、C1-6 烷基、C1-6 烷氧基、羟基、硝基、氰基或氨基，其中 C1-6 烷基、C1-6 烷氧基和氨基可被 1 至 5 个取代基取代，Y 是 C 或 N；环 B 是任选取代的苯环；m = 1 至 4，n = 0 至 2；L 代表离去基团，如卤素原子、烷基磺酰基、烷基磺酰氧基和芳基磺酰氧基；或其盐。
• Tricylic compounds having binding affinity for melatonin receptors, their production and use
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP0885210B2

  公开（公告）日：2008-06-18
• US6034239A
  申请人：——

  公开号：US6034239A

  公开（公告）日：2000-03-07
• US6218429B1
  申请人：——

  公开号：US6218429B1

  公开（公告）日：2001-04-17