2-[{4-(2-(2-Methoxyethoxy))ethoxy-3-methylpyridine-2-yl}methylsulfinyl]-5-trifluoromethyl-1H-benzimidazole | 117977-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[{4-(2-(2-Methoxyethoxy))ethoxy-3-methylpyridine-2-yl}methylsulfinyl]-5-trifluoromethyl-1H-benzimidazole
• 英文别名: 2-[[4-[2-(2-methoxyethoxy)ethoxy]-3-methylpyridin-2-yl]methylsulfinyl]-6-(trifluoromethyl)-1H-benzimidazole
• CAS: 117977-45-4
• 化学式: C₂₀H₂₂F₃N₃O₄S
• 分子量: 457.474
• InChiKey: OSIIZJSXFIBRPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same
  申请人：Eisai Co., Ltd.

  公开号：EP0786461A1

  公开（公告）日：1997-07-30

  The invention provides pyridine derivatives represented by the general formula: wherein R1 and R2 may be the same or different from each other and each stand for a hydrogen atom, a C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkyl, (C1-6 alkoxy) carbonyl or carboxyl group or a halogen atom; X stands for a group represented by the formula: -O-, -S-or (wherein R3 stands for a hydrogen atom or a C1-6 alkyl, phenyl, benzyl or (C1-6 alkoxy)carbonyl group); Z stands for ① a group represented by the general formula:         -0-(CH2)q-R5 wherein q stands for an integer of 1 to 3 and R5 stands for a halogen atom or an (C1-6 alkoxy) carbonyl, aryl or heteroaryl group, ② a group represented by the general formula:         -0-(CH2)r-0-(CH2)s-0-R6 wherein r and s each stand for an integer of 1 to 5 and R6 stands for a hydrogen atom or a C1-6 alkyl group, ③ a group represented by the formula: ④ a group represented by the general formula: wherein t stands for an integer of 0 to 2 and A stands for a group represented by the general formula: (wherein B stands for a group represented by the formula: -NH-, -0- or -S-), a C1-6 aklyl, (C1-6 alkoxy)carbonylmethyl, pyridyl or furyl group or a group represented by the general formula: (wherein R7 stands for a hydrogen atom, a C1-6 alkyl or C1-6 alkoxy group or a halogen atom and w stands for an integer of 0 or 1), ⑤ a group represented by the general formula: wherein R8 stands for an acetoxy or C1-6 alkyl group, n stands for an integer of 0 to 2, m stands for an integer of 2 to 10, and J and K may be the same or different from each other and each stand for a hydrogen atom or a C1-6 alkyl group, and a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising these derivatives are also provided, together with the use of the derivatives for the manufacture of medicaments having therapeutic or preventative value in the treatment of peptic ulcers. Processes for preparing such pyridine derivatives are also provided.

  本发明提供了由一般式表示的吡啶衍生物：其中R1和R2可以相同或不同，分别代表氢原子，C1-6烷基，C1-6烷氧基，卤代C1-6烷基，(C1-6烷氧基)羰基或羧基或卤原子；X代表由公式表示的基团：-O-，-S-或（其中R3代表氢原子或C1-6烷基，苯基，苄基或（C1-6烷氧基）羰基）；Z代表①由一般式表示的基团：-0-（CH2）q-R5，其中q为1至3的整数，R5为卤原子或（C1-6烷氧基）羰基，芳基或杂芳基基团，②由一般式表示的基团：-0-（ ）r-0-（ ）s-0-R6，其中r和s分别为1至5的整数，R6为氢原子或C1-6烷基基团，③由公式表示的基团：④由一般式表示的基团：其中t为0至2的整数，A代表由一般式表示的基团：（其中B代表- NH-，-0-或-S-表示的基团），C1-6烷基，（C1-6烷氧基）羰基甲基，吡啶基或呋喃基团或由一般式表示的基团：（其中R7代表氢原子，C1-6烷基或C1-6烷氧基基团或卤原子，w代表0或1），⑤由一般式表示的基团：其中R8代表乙酰氧基或C1-6烷基基团，n为0至2的整数，m为2至10的整数，J和K可以相同或不同，分别代表氢原子或C1-6烷基基团，并且其药学上可接受的盐。还提供了包含这些衍生物的制药组合物，以及这些衍生物在制造具有治疗或预防胃溃疡价值的药物方面的用途。还提供了制备这种吡啶衍生物的方法。
• Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and process for preparing the same
  申请人：Eisai Co., Ltd.

  公开号：EP0654471A1

  公开（公告）日：1995-05-24

  The invention provides pyridine derivatives represented by general formula: wherein R¹ and R² may be the same or different from each other and each stand for a hydrogen atom, a C₁₋₆ alkyl, C₁₋₆ alkoxy, halogenated C₁₋₆ alkyl, (C₁₋₆ alkoxy)carbonyl or carboxyl group or a halogen atom; X stands for a group represented by the formula: -O-, -S- or (wherein R³ stands for a hydrogen atom or a C₁₋₆ alkyl, phenyl, benzyl or (C₁₋₆ alkoxy)carbonyl group); Z stands for ① a group represented by the general formula:         -O-(CH₂)q-R⁵ wherein q stands for an integer of 1 to 3 and R⁵ stands for a naphthyl group, which may be substituted with a C₁₋₆ alkoxy group, a hydroxyl group or a halogen atom; a pyridyl group or a furyl group, ② a group represented by the general formula:         ―OR⁹    wherein OR⁹ stands for a phenyl, tolyl, xylyl or naphthyl group, n stands for an integer of 0 to 2; m stands for an integer of 2 to 10; and J and K may be the same or different from each other and each stand for a hydrogen atom or a C₁₋₆ alkyl group, and a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising these derivatives are also provided, together with the use of the derivatives for the manufacture of medicaments having therapeutic or preventative value in the treatment of peptic ulcers. Processes for preparing such pyridine derivatives are also provided.

  本发明提供由通式表示的吡啶衍生物： 其中 R¹ 和 R² 可以相同或互不相同，各自代表氢原子、C₁₋₆ 烷基、C₁₋₆ 烷氧基、卤代 C₁₋₆ 烷基、(C₁₋₆ 烷氧基)羰基或羧基或卤原子； X 代表由式表示的基团： -O-、-S- 或 (其中 R³ 代表氢原子或 C₁₋₆ 烷基、苯基、苄基或 (C₁₋₆ 烷氧基)羰基）； Z 代表 由通式表示的基团： -O-(CH₂)q-R⁵ 其中 q 代表 1 至 3 的整数，R⁵ 代表萘基，可被 C₁₋₆烷氧基、羟基或卤素原子、吡啶基或呋喃基取代、 由通式表示的基团： -由通式表示的基团 其中 OR𠞙 代表苯基、甲苯基、二甲苯基或萘基、 n 代表 0 至 2 的整数；m 代表 2 至 10 的整数；以及 J 和 K 可以相同或不同，各自代表一个氢原子或一个 C₁₋₆ 烷基、 及其药学上可接受的盐。 此外，还提供了包含这些衍生物的药物组合物，以及这些衍生物在制造具有治疗或预防消化性溃疡价值的药物时的用途。还提供了制备此类吡啶衍生物的工艺。
• US5045552A
  申请人：——

  公开号：US5045552A

  公开（公告）日：1991-09-03
• US5840910A
  申请人：——

  公开号：US5840910A

  公开（公告）日：1998-11-24
• US5998445A
  申请人：——

  公开号：US5998445A

  公开（公告）日：1999-12-07