methyl 2-methyl-2-(piperidin-4-yl)propanoate | 861772-99-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-methyl-2-(piperidin-4-yl)propanoate
• 英文别名: methyl 2-methyl-2-piperidin-4-ylpropanoate
• CAS: 861772-99-8
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: JLVMWOWMOBDLLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-二氯嘧啶 、 methyl 2-methyl-2-(piperidin-4-yl)propanoate 以81 %的产率得到methyl 2-(1-(2-chloropyrimidin-4-yl)piperidin-4-yl)-2-methylpropanoate
  参考文献：
  名称：

  NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF

  摘要：

  本发明涉及一种氨基苯衍生物化合物，由化学式(1)表示，并表现出二酰基甘油酰基转移酶2(DGAT2)抑制剂的活性，包含该化合物作为活性成分的药剂组合物，以及该化合物的用途。

  公开号：

  EP4071147A1

文献信息

• [EN] DIAMINO ALCOHOLS AND THEIR USE AS RENIN INHIBITORS<br/>[FR] DIAMINOALCOOLS ET UTILISATION DE CEUX-CI EN TANT QU'INHIBITEURS DE LA RENINE
  申请人：SPEEDEL EXPERIMENTA AG

  公开号：WO2005070877A1

  公开（公告）日：2005-08-04

  The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.

  该申请涉及一类新颖的氨基酸醇，其通用公式为(I)，其中R、R1、R2、R3、R4、R5和R6的定义在描述中详细说明，还涉及这些化合物的制备方法，以及将这些化合物用作药物，特别是作为肾素抑制剂的使用。
• DIAMINO ALCOHOLS AND THEIR USE AS RENIN INHIBITORS
  申请人：Speedel Experimenta AG

  公开号：EP1735270A1

  公开（公告）日：2006-12-27
• AMINO ALCOHOL DERIVATIVES AND THEIR ACTIVITY AS RENIN INHIBITORS
  申请人：Speedel Experimenta AG

  公开号：EP1756037A2

  公开（公告）日：2007-02-28
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSES ORGANIQUES
  申请人：SPEEDEL EXPERIMENTA AG

  公开号：WO2005070871A2

  公开（公告）日：2005-08-04

  The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
• [EN] NOVEL AMINO ARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR AND USE THEREOF<br/>[FR] NOUVEAU DÉRIVÉ AMINO-ARYLE UTILE EN TANT QU'INHIBITEUR DE DIACYLGLYCÉROL ACYLTRANSFÉRASE 2 ET SON UTILISATION<br/>[KO] 디아실글리세롤 아실트랜스퍼라제 2 억제제로서 유용한 신규 아미노 아릴 유도체 및 이의 용도
  申请人：LG CHEMICAL LTD

  公开号：WO2021133035A1

  公开（公告）日：2021-07-01

  본 발명은 디아실글리세롤 아실트랜스퍼라제 2(diacylglycerol acyltransferase 2, DGAT2) 억제제 활성을 나타내는 화학식 (1)로 표시되는 아미노 아릴 유도체 화합물, 이를 활성성분으로 포함하는 약제학적 조성물 및 용도에 관한 것이다.