1-allyloxy-4-iodo-2-trifluoromethoxybenzene | 647855-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-allyloxy-4-iodo-2-trifluoromethoxybenzene
• 英文别名: 4-Iodo-1-[(prop-2-en-1-yl)oxy]-2-(trifluoromethoxy)benzene；4-iodo-1-prop-2-enoxy-2-(trifluoromethoxy)benzene
• CAS: 647855-30-9
• 化学式: C₁₀H₈F₃IO₂
• 分子量: 344.072
• InChiKey: PLJSHXRGRJSSND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• N-hydroxyamide derivatives possessing antibacterial activity
  申请人：Raju Bore G.

  公开号：US20080058304A1

  公开（公告）日：2008-03-06

  Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.

  本发明揭示了新型N-羟基酰胺衍生物。这些N-羟基酰胺衍生物能够抑制存在于革兰氏阴性菌中的UPD-3-O-(R-3-羟基肉豆蔻酰)-N-乙酰葡萄糖胺脱乙酰酶，因此可用作抗微生物和抗生素。本发明还揭示了所述化合物的合成和使用方法。
• EP1539744A4
  申请人：——

  公开号：EP1539744A4

  公开（公告）日：2007-06-06
• N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1539744A2

  公开（公告）日：2005-06-15
• US7691843B2
  申请人：——

  公开号：US7691843B2

  公开（公告）日：2010-04-06
• [EN] N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY<br/>[FR] DERIVES DE N-HYDROXYAMIDE AYANT UNE ACTIVITE ANTI-BACTERIENNE
  申请人：VICURON PHARM INC

  公开号：WO2004007444A2

  公开（公告）日：2004-01-22

  Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.