2-氯-N-[2-(4-氯苯基)-4-羟基苯基]吡啶-3-羧酰胺 | 661463-87-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-N-[2-(4-氯苯基)-4-羟基苯基]吡啶-3-羧酰胺
• 中文别名: 羟基鳞甲虫
• 英文名称: 2-chloro-N-(4'-chloro-5-hydroxybiphenyl-2-yl)nicotinamide
• 英文别名: boscalid；M510F01；2-Chloro-N-(4'-chloro-5-hydroxy[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide；2-chloro-N-[2-(4-chlorophenyl)-4-hydroxyphenyl]pyridine-3-carboxamide
• CAS: 661463-87-2
• 化学式: C₁₈H₁₂Cl₂N₂O₂
• 分子量: 359.211
• InChiKey: GLTMLPGXPMAIOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  4-溴丁酸乙酯 、 2-氯-N-[2-(4-氯苯基)-4-羟基苯基]吡啶-3-羧酰胺 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  CN116730914

  摘要：

  公开号：
• 作为产物：
  描述：

  啶酰菌胺 在 三氟乙酸 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 氯仿 为溶剂， 反应 3.0h， 生成 2-氯-N-[2-(4-氯苯基)-4-羟基苯基]吡啶-3-羧酰胺
  参考文献：
  名称：

  Highly sensitive monoclonal antibody-based immunoassays for boscalid analysis in strawberries

  摘要：

  Boscalid is an agrochemical recently developed for crop protection and the most significant member of the succinate dehydrogenase inhibitor group of fungicides. In this study, a collection of high-affinity monoclonal antibodies was generated to boscalid. By using a series of haptens with a linker at alternative tethering sites of the boscalid framework, specific antibodies were isolated as well as antibodies that also recognized the main boscalid metabolite. Two immunoassays were developed using different ELISA formats. Optimized assays displayed very high sensitivities (limits of detection were near 0.01 mu g/L). Trueness and precision for the determination of the target analyte in strawberry samples was evaluated. Moreover, immunoassay performance was validated with a reference chromatographic method using QuEChERS extracts of fruits from fungicide-treated crops. A monitoring study with strawberry samples from local markets was carried out by immunoassay, showing an occurrence of boscalid of 15% with a maximum residue concentration of 43 mu g/kg. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.foodchem.2017.06.013

文献信息

• Site‐Selective C−H Oxygenation via Aryl Sulfonium Salts
  作者：Ruocheng Sang、Stamatis E. Korkis、Wanqi Su、Fei Ye、Pascal S. Engl、Florian Berger、Tobias Ritter

  DOI：10.1002/anie.201908718

  日期：2019.11.4

  Herein, we report a two-step process forming arene C-O bonds in excellent site-selectivity at a late-stage. The C-O bond formation is achieved by selective introduction of a thianthrenium group, which is then converted into C-O bonds using photoredox chemistry. Electron-rich, -poor and -neutral arenes as well as complex drug-like small molecules are successfully transformed into both phenols and various

  在此，我们报告了一种在后期以优异的位点选择性形成芳烃CO键的两步过程。CO 键的形成是通过选择性引入铊基团来实现的，然后使用光氧化还原化学将其转化为 CO 键。富电子、贫电子和中性芳烃以及复杂的类药物小分子被成功转化为酚类和各种醚类。该序列在概念上不同于所有先前的芳烃氧化反应，因为氧官能团可以在后期选择性地结合到复杂的小分子中，这尚未通过芳基卤化物显示出来。